{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:40:54Z","timestamp":1777110054381,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ocular adnexal MALT lymphoma (OAML) is linked to<jats:italic>Chlamydophila psittaci (Cp<\/jats:italic>) infection. Viability and infectivity of<jats:italic>Cp<\/jats:italic>, demonstrated by growth in culture, has not been yet investigated in these patients. We conducted a single\u2010center prospective case\u2013control study to assess the prevalence, viability and infectivity of<jats:italic>Cp<\/jats:italic>in 20 OAML patients and 42 blood donors registered in a 6\u2010month period. The presence of<jats:italic>Cp<\/jats:italic>in conjunctival swabs and peripheral blood mononuclear cells (PBMC) of patients and donors was assessed by TETR\u2010PCR and<jats:italic>in vitro<\/jats:italic>cultures. From an epidemiological point of view, OAML patients often resided in rural areas, and reported a history of chronic conjunctivitis and prolonged contact with household animals (85%<jats:italic>vs<\/jats:italic>. 38% of donors;<jats:italic>p<\/jats:italic>= 0.00001).<jats:italic>Cp<\/jats:italic>was detected in lymphoma tissue in 15 (75%) patients.<jats:italic>Cp<\/jats:italic>DNA was detected in conjunctival swabs and\/or PBMC from 10 (50%) patients and in PBMC from 1 (2%) donor (<jats:italic>p<\/jats:italic>= 0.01). Viability and infectivity of<jats:italic>Cp<\/jats:italic>, demonstrated by growth in culture, were confirmed in conjunctival swabs and\/or PBMC from 5 (25%) patients, but not in donors (<jats:italic>p<\/jats:italic>= 0.002). This prospective study demonstrates, for the first time, that<jats:italic>Cp<\/jats:italic>present in the conjunctiva and PBMC of OAML patients is capable to grow and be isolated in cell cultures.<jats:italic>Cp<\/jats:italic>infection is common in OAML patients and exceptional in blood donors. Epidemiological data of OAML patients (prolonged contact with household animals and chronic conjunctivitis) are consistent with<jats:italic>Cp<\/jats:italic>exposure risk. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23596","type":"journal-article","created":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T18:47:29Z","timestamp":1212605249000},"page":"1089-1093","source":"Crossref","is-referenced-by-count":62,"title":["<i>Chlamydophila psittaci<\/i>is viable and infectious in the conjunctiva and peripheral blood of patients with ocular adnexal lymphoma: Results of a single\u2010center prospective case\u2013control study"],"prefix":"10.1002","volume":"123","author":[{"given":"Andr\u00e9s J.M.","family":"Ferreri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Dolcetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina P.","family":"Dognini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Malabarba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Vicari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Pasini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurilio","family":"Ponzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Giulia","family":"Cangi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenza","family":"Pecciarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Giordano","family":"Resti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Doglioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvano","family":"Rossini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Magnino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh102"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-51-1-203"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0204.960406"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj373"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.083"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.47.31"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008396618983"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-145-2-411"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.3.1085-1093.2000"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.02.094"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655499750006164"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/03079450310001593613"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-23"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.58.4.686-699.1994"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2003.08.005"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"834","DOI":"10.2460\/javma.1993.203.06.0834","article-title":"Clinical and laboratory findings in chronic conjunctivitis in cats: 91 cases (1983\u20131991)","volume":"203","author":"Nasisse MP","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1086\/516373"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djm118"},{"key":"e_1_2_6_20_2","first-page":"389","volume-title":"CRC handbook of zoonoses","author":"Grimes JE","year":"1994"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.23596","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.23596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T02:04:18Z","timestamp":1708999458000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.23596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,4]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["10.1002\/ijc.23596"],"URL":"https:\/\/doi.org\/10.1002\/ijc.23596","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,4]]}}}