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We prospectively examined if chronic rhinitis or sinusitis was associated with lung cancer risk in the Singapore Chinese Health Study, a population\u2010based cohort of 63,257 Singapore Chinese, who were aged 45\u201374 years when recruited between 1993 and 1998. Each subject completed a comprehensive interview on medical conditions, dietary and lifestyle factors at recruitment, and cancer occurrence and survival status were determined<jats:italic>via<\/jats:italic>linkage to population\u2010based registries. As of 31 December, 2005, 954 cohort participants had developed lung cancer. Compared with subjects without such history, subjects who reported a history of physician\u2010diagnosed rhinitis or sinusitis at baseline, whether allergic or nonallergic, had a statistically significant 59% increase in risk of lung cancer (hazard ratio [HR] = 1.59; confidence interval [CI] = 1.06\u20132.37). This association was significant and stronger in women (HR = 2.32; 95% CI = 1.23\u20134.39) compared to men, and for the adenocarcinoma cell type (HR = 1.91; 95% CI = 1.07\u20133.42) compared to other histologies. Overall, a history of asthma, hay fever, allergic dermatitis, food allergy or any other allergic conditions asked in a single question was not related to lung cancer risk (HR = 1.11; 95% CI = 0.90\u20131.36). Chronic rhinosinusitis may be a marker of pan\u2010airway inflammation and its association with lung cancer risk provides evidence linking inflammation to lung carcinogenesis, especially among women. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23623","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T21:46:29Z","timestamp":1213220789000},"page":"1398-1402","source":"Crossref","is-referenced-by-count":20,"title":["Chronic rhinosinusitis and risk of lung cancer in the Singapore Chinese Health 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