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Liquid\u2010based cytology samples (SurePath\u00ae) were collected consecutively. HPV testing was performed with Hybrid Capture 2 (HC2; Digene) (high\u2010risk and low\u2010risk probes), and LiPA (Innogenetics) was used for genotyping. We analyzed samples from 11,617 women; 94.0% had normal cytology, 4.3% atypical squamous cells of undetermined significance or low\u2010grade squamous intraepithelial lesion and 1.6% had high\u2010grade squamous intraepithelial lesion (HSIL). The HPV prevalence was 26.4% with a peak in women 20\u201324 years (50.2%) and then decreased without a second peak in older women. Among the youngest women (15\u201319 years), 14% had HPV 16\/18 and 16% had HPV 6\/11. Prevalence of high\u2010risk HPV types increased from 19.2% in women with normal cytology to 100% in women with cervical intraepithelial neoplasia grade 3 (CIN3)\/cervical cancer. HPV 16 was the most prevalent type (6.0% of all women), and was also the most prevalent in women with HSIL (35.1%) and CIN3 (53.2%). Other common HPV types in women with CIN3 included HPV 52, 51, 31, 33 and 18. HPV 16\/18 alone was present in 23% of CIN3 lesions and 67% of cervical cancers, and HPV 16\/18 together with other high\u2010risk HPV types was present in 41% of CIN3 lesions. This suggests that an efficacious HPV 16\/18 vaccine will have a substantial preventive potential in the general female population. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23712","type":"journal-article","created":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T18:58:15Z","timestamp":1217012295000},"page":"1864-1870","source":"Crossref","is-referenced-by-count":144,"title":["Population\u2010based prevalence, type\u2010 and age\u2010specific distribution of HPV in women before introduction of an HPV\u2010vaccination program in Denmark"],"prefix":"10.1002","volume":"123","author":[{"given":"Susanne K.","family":"Kj\u00e6r","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Breugelmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Munk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jette","family":"Junge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Iftner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8,13]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide, IARC CancerBase No. 5. 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