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We studied the engraftment kinetics of AML and ALL cell lines and primary cells in 3 strains of NOD.CB17\u2010<jats:italic>Prkdc<jats:sup>scid<\/jats:sup><\/jats:italic> (NOD\/<jats:italic>scid<\/jats:italic>, NS)\u2010related mice (NOD.Cg\u2010<jats:italic>Prkdc<jats:sup>scid<\/jats:sup>B2m<jats:sup>tm1Unc<\/jats:sup><\/jats:italic>\/J, abbreviated NOD\/<jats:italic>scid<\/jats:italic>\/\u03b22 null, NSB; and NOD.Cg\u2010<jats:italic>Prkdc<jats:sup>scid<\/jats:sup>Il2rg<jats:sup>tm1Wjll<\/jats:sup><\/jats:italic>\/SzJ, abbreviated NOD\/<jats:italic>scid<\/jats:italic>\/IL\u20102R\u03b3 null, NSG). The engraftment of human malignant cells was investigated by means of clinicopathological criteria, flow cytometry, PCR and immunohistochemistry. In NSG mice, we observed a significantly faster development of leukemia\u2010related symptoms and a higher percentage of leukemia cells in the blood, in the marrow and in the spleen. The leukemia\u2010related angiogenic switch (measured as the number of circulating endothelial cells and progenitors) was faster in NSG compared to NS and NSB mice. These models will be instrumental to studies on leukemia\u2010initiating stem cells, leukemia biology, preclinical treatment studies, and to obtain patient\u2010specific preclinical models to design and investigate patient\u2010tailored therapies. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23772","type":"journal-article","created":{"date-parts":[[2008,8,7]],"date-time":"2008-08-07T19:33:15Z","timestamp":1218137595000},"page":"2222-2227","source":"Crossref","is-referenced-by-count":150,"title":["Human acute leukemia cells injected in NOD\/LtSz\u2010<i>scid\/IL\u20102R\u03b3<\/i> null mice generate a faster and more efficient disease compared to other NOD\/<i>scid<\/i>\u2010related 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