{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:11:22Z","timestamp":1791223882565,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T00:00:00Z","timestamp":1220313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exposure to ionizing radiation has been consistently associated with increased risk of female breast cancer. Although the majority of DNA damage caused by ionizing radiation is corrected by the base\u2010excision repair pathway, certain types of multiple\u2010base damage can only be repaired through the nucleotide excision repair pathway. In a nested case\u2013control study of breast cancer in US radiologic technologists exposed to low levels of ionizing radiation (858 cases, 1,083 controls), we examined whether risk of breast cancer conferred by radiation was modified by nucleotide excision gene polymorphisms <jats:italic>ERCC2 (XPD<\/jats:italic>) rs13181, <jats:italic>ERCC4 (XPF<\/jats:italic>) rs1800067 and rs1800124, <jats:italic>ERCC5 (XPG<\/jats:italic>) rs1047769 and rs17655; and <jats:italic>ERCC6<\/jats:italic> rs2228526. Of the 6 <jats:italic>ERCC<\/jats:italic> variants examined, only <jats:italic>ERCC5<\/jats:italic> rs17655 showed a borderline main effect association with breast cancer risk (OR<jats:sub>GC<\/jats:sub> = 1.1, OR<jats:sub>CC<\/jats:sub> = 1.3; <jats:italic>p<\/jats:italic>\u2010trend = 0.08), with some indication that individuals carrying the C allele variant were more susceptible to the effects of occupational radiation (EOR\/Gy<jats:sub>GG<\/jats:sub> = 1.0, 95% CI = &lt;0, 6.0; EOR\/Gy<jats:sub>GC\/CC<\/jats:sub> = 5.9, 95% CI = 0.9, 14.4; <jats:italic>p<\/jats:italic><jats:sub>het<\/jats:sub> = 0.10). <jats:italic>ERCC2<\/jats:italic> rs13181, although not associated with breast cancer risk overall, statistically significantly modified the effect of occupational radiation dose on risk of breast cancer (EOR\/Gy<jats:sub>AA<\/jats:sub> = 9.1, 95% CI = 2.1\u221221.3; EOR\/Gy<jats:sub>AC\/CC<\/jats:sub> = 0.6, 95% CI = &lt;0, 4.6; <jats:italic>p<\/jats:italic><jats:sub>het<\/jats:sub> = 0.01). These results suggest that common variants in nucleotide excision repair genes may modify the association between occupational radiation exposure and breast cancer risk. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23779","type":"journal-article","created":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T13:35:39Z","timestamp":1220362539000},"page":"2713-2716","source":"Crossref","is-referenced-by-count":52,"title":["Nucleotide excision repair polymorphisms may modify ionizing radiation\u2010related breast cancer risk in US radiologic technologists"],"prefix":"10.1002","volume":"123","author":[{"given":"Preetha","family":"Rajaraman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parveen","family":"Bhatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Morin","family":"Doody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Weinstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha S.","family":"Linet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin","family":"Rosenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Stovall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce H.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale 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