{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:21:05Z","timestamp":1775305265707,"version":"3.50.1"},"reference-count":70,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T00:00:00Z","timestamp":1218758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Few studies on the association between nucleotide excision repair (NER) variants and lung cancer risk have included Latinos and African Americans. We examine variants in 6 NER genes (<jats:italic>ERCC2<\/jats:italic>, <jats:italic>ERCC4<\/jats:italic>, <jats:italic>ERCC5<\/jats:italic>, <jats:italic>LIG1<\/jats:italic>, <jats:italic>RAD23B<\/jats:italic> and <jats:italic>XPC<\/jats:italic>) in association with primary lung cancer risk among 113 Latino and 255 African American subjects newly diagnosed with primary lung cancer from 1998 to 2003 in the San Francisco Bay Area and 579 healthy controls (299 Latinos and 280 African Americans). Individual single nucleotide polymorphism and haplotype analyses, multifactor dimensionality reduction (MDR) and principal components analysis (PCA) were performed to assess the association between 6 genes in the NER pathway and lung cancer risk. Among Latinos, <jats:italic>ERCC2<\/jats:italic> haplotype CGA (rs238406, rs11878644, rs6966) was associated with reduced lung cancer risk [odds ratio (OR) of 0.65 and 95% confidence interval (CI): 0.44\u20130.97], especially among nonsmokers (OR = 0.29; 95% CI: 0.12\u20130.67). From MDR analysis, in Latinos, smoking and 3 SNPs (<jats:italic>ERCC2<\/jats:italic> rs171140, <jats:italic>ERCC5<\/jats:italic> rs17655 and <jats:italic>LIG1<\/jats:italic> rs20581) together had a prediction accuracy of 67.4% (<jats:italic>p<\/jats:italic> = 0.001) for lung cancer. Among African Americans, His\/His genotype of <jats:italic>ERCC5<\/jats:italic> His1104Asp (rs17655) was associated with increased lung cancer risk (OR = 1.78; 95% CI: 1.09\u20132.91), and <jats:italic>LIG1<\/jats:italic> haplotype GGGAA (rs20581, rs156641, rs3730931, rs20579 and rs439132) was associated with reduced lung cancer risk (OR = 0.61; 95% CI: 0.42\u20130.88). Our study suggests different elements of the NER pathway may be important in the different ethnic groups resulting either from different linkage relationship, genetic backgrounds and\/or exposure histories. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23801","type":"journal-article","created":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T12:43:50Z","timestamp":1218804230000},"page":"2095-2104","source":"Crossref","is-referenced-by-count":64,"title":["Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans"],"prefix":"10.1002","volume":"123","author":[{"given":"Jeffrey S.","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret R.","family":"Wrensch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen 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