{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:44:48Z","timestamp":1772192688127,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,9,3]],"date-time":"2008-09-03T00:00:00Z","timestamp":1220400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2008,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ultraviolet radiation is the major cause of skin cancer, but promotes vitamin D synthesis, and vitamin D has been inversely related to the risk of several common cancers including prostate, breast and colorectum. We therefore computed the incidence of prostate, breast and colorectal cancer following skin cancer using the datasets of the Swiss cancer Registries of Vaud and Neuch\u00e2tel. Between 1974 and 2005, 6,985 histologically confirmed squamous cell skin cancers, 21,046 basal cell carcinomas and 3,346 cutaneous malignant melanomas were registered, and followed up to the end of 2005 for the occurrence of second primary cancer of the prostate, breast and colorectum. Overall, 680 prostate cancers were observed <jats:italic>versus<\/jats:italic> 568.3 expected (standardized incidence ratio (SIR) = 1.20; 95% confidence interval (CI): 1.11\u20131.29), 440 breast cancers were observed <jats:italic>versus<\/jats:italic> 371.5 expected (SIR = 1.18; 95% CI: 1.08\u20131.30) and 535 colorectal cancers were observed <jats:italic>versus<\/jats:italic> 464.6 expected (SIR = 1.15; 95% CI: 1.06\u20131.25). When basal cell, squamous cell and skin melanoma were considered separately, all the SIRs for prostate, breast and colorectal cancers were around or slightly above unity. Likewise, the results were consistent across strata of age at skin cancer diagnosis and location (head and neck <jats:italic>versus<\/jats:italic> others), and for male and female colorectal cancers. These findings, based on a population with a long tradition of systematic histologic examination of all surgically treated skin lesions, do not support the hypothesis that prostate, breast and colorectal cancer risk is decreased following skin cancer. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23816","type":"journal-article","created":{"date-parts":[[2008,9,3]],"date-time":"2008-09-03T18:10:20Z","timestamp":1220465420000},"page":"2899-2901","source":"Crossref","is-referenced-by-count":33,"title":["Risk of prostate, breast and colorectal cancer after skin cancer diagnosis"],"prefix":"10.1002","volume":"123","author":[{"given":"Fabio","family":"Levi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalao","family":"Randimbison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van\u2010Cong","family":"Te","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela Maspoli","family":"Conconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,15]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/9.3.227"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn053"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwk084"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)05788-9"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-3134"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.03.023"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2006.12.007"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-004-1661-4"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn077"},{"key":"e_1_2_5_11_2","article-title":"Dietary vitamin D intake and cancers of the colon and rectum: a case\u2010control study in Italy","author":"Lipworth L","journal-title":"Nutr Cancer"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970904)72:5<776::AID-IJC12>3.0.CO;2-7"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009516"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009349"},{"key":"e_1_2_5_15_2","series-title":"Cancer incidence in five continents","first-page":"452","author":"Levi F","year":"2002"},{"key":"e_1_2_5_16_2","series-title":"Cancer incidence in five continents","first-page":"460","author":"Levi F","year":"2002"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/17.4.711"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1995.460"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23306.x"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07892.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.7.781"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03892.x"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008209005622"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.12.015"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-1053"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm259"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.23816","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.23816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T03:01:51Z","timestamp":1695956511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.23816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,15]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12,15]]}},"alternative-id":["10.1002\/ijc.23816"],"URL":"https:\/\/doi.org\/10.1002\/ijc.23816","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,15]]}}}