{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:25:21Z","timestamp":1791181521567,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T00:00:00Z","timestamp":1220313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The t(14;18) translocation is a common genetic aberration that can be seen as an early step in pathogenesis of follicular lymphoma (FL). The significance of low level circulating t(14;18)\u2010positive cells in healthy individuals as clonal lymphoma precursors or indicators of risk is still unclear. We determined the age dependent prevalence and frequency of BCL2\/IgH rearrangements in 715 healthy individuals ranging from newborns to octo\u2010 and nonagenarians. These results were compared with number of circulating t(14;18)\u2010positive cells in 108 FL patients at initial presentation. The overall prevalence of BCL2\/IgH junctions in this large sample was 46% (327\/715). However, there was a striking dependence upon age. Specifically, among individuals up to 10 years old, none had detectable circulating t(14;18)\u2010positive cells. In the age groups representing 10\u201350 years old, we found a steady elevation in the prevalence of BCL2\/IgH junctions up to a prevalence of 66%. Further increases of the prevalence in individuals older than 50 years were not seen. The mean frequency of BCL2\/IgH junctions in healthy individuals \u226540 years (18\u201326 \u00d7 10<jats:sup>\u22126<\/jats:sup>) was significantly higher than in younger subjects (7\u20139 \u00d7 10<jats:sup>\u22126<\/jats:sup>). Four percent (31\/715) of individuals carried more than one t(14;18)\u2010positive cell per 25,000 peripheral blood mononuclear cells (PBMNCs). In comparison, 108 stage III\/IV FL patients had a median number of circulating t(14;18)\u2010positive malignant FL cells of about 9200\/1 million PBMNCs (range 7\u20131,000,000). These findings will further improve the understanding of the relevance of t(14;18)\u2010positive cells in healthy individuals as a risk marker toward the development into lymphoma precursors. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23958","type":"journal-article","created":{"date-parts":[[2008,9,2]],"date-time":"2008-09-02T18:26:07Z","timestamp":1220379967000},"page":"958-963","source":"Crossref","is-referenced-by-count":86,"title":["Prevalence and frequency of circulating t(14;18)\u2010MBR translocation carrying cells in healthy 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