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However, PUFA food sources are diverse in human diets and few epidemiologic studies have examined whether associations between dietary PUFAs and breast cancer risk vary according to food sources or antioxidant intakes. The relationship between individual PUFA intakes estimated from diet history questionnaires and breast cancer risk was examined among 56,007 French women. During 8 years of follow\u2010up, 1,650 women developed invasive breast cancer. Breast cancer risk was not related to any dietary PUFA overall; however, opposite associations were seen according to food sources, suggesting other potential effects than PUFA <jats:italic>per se<\/jats:italic>. Breast cancer risk was inversely associated with \u03b1\u2010linolenic acid (ALA) intake from fruit and vegetables [highest <jats:italic>vs.<\/jats:italic> lowest quintile, hazard ratio (HR) 0.74; 95% confidence interval (CI) 0.63, 0.88; <jats:italic>p<\/jats:italic> trend &lt; 0.0001], and from vegetable oils (HR 0.83; 95% CI 0.71, 0.97; <jats:italic>p<\/jats:italic> trend 0.017). Conversely, breast cancer risk was positively related to ALA intake from nut mixes (<jats:italic>p<\/jats:italic> trend 0.004) and processed foods (<jats:italic>p<\/jats:italic> trend 0.068), as was total ALA intake among women in the highest quintile of dietary vitamin E (<jats:italic>p<\/jats:italic> trend 0.036). A significant interaction was also found between \u03c9\u20106 and long\u2010chain \u03c9\u20103 PUFAs, with breast cancer risk inversely related to long\u2010chain \u03c9\u20103 PUFAs in women belonging to the highest quintile of \u03c9\u20106 PUFAs (<jats:italic>p<\/jats:italic> interaction 0.042). These results emphasize the need to consider food sources, as well as interactions between fatty acids and with antioxidants, when evaluating associations between PUFA intakes and breast cancer risk. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.23980","type":"journal-article","created":{"date-parts":[[2008,9,9]],"date-time":"2008-09-09T12:53:34Z","timestamp":1220964814000},"page":"924-931","source":"Crossref","is-referenced-by-count":131,"title":["Dietary intakes of \u03c9\u20106 and \u03c9\u20103 polyunsaturated fatty acids and the risk of breast cancer"],"prefix":"10.1002","volume":"124","author":[{"given":"Anne C.M.","family":"Thi\u00e9baut","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Chaj\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariette","family":"Gerber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Boutron\u2010Ruault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Joulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Lenoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Berrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elio","family":"Riboli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"B\u00e9nichou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Clavel\u2010Chapelon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,11,26]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"GLOBOCAN 2000: cancer incidence, mortality and prevalence worldwide, version 1.0","author":"Ferlay J","year":"2001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11661"},{"key":"e_1_2_6_4_2","unstructured":"Molini\u00e9F ColonnaM. 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