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However, for screening purposes the detection of high\u2010risk HPV is not inherently useful unless it is informative for the presence of high\u2010grade cervical intraepithelial neoplasia (CIN 2\/3) or cancer. Candidate high\u2010risk HPV tests to be used for screening should reach an optimal balance between clinical sensitivity and specificity for detection of high\u2010grade CIN and cervical cancer to minimize redundant or excessive follow\u2010up procedures for high\u2010risk HPV positive women without cervical lesions. Data from various large screening studies have shown that high\u2010risk HPV testing by hybrid capture 2 and GP5+\/6+\u2010PCR yields considerably better results in the detection of CIN 2\/3 than cytology. The data from these studies can be used to guide the translation of high\u2010risk HPV testing into clinical practice by setting standards of test performance and characteristics. 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