{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T09:33:39Z","timestamp":1771752819718,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T00:00:00Z","timestamp":1221782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The natural history of human T\u2010lymphotropic virus type I (HTLV\u2010I) has been shown to differ markedly by geographic area. The differences include contrasting patterns of risk of adult T\u2010cell lymphoma (ATL) and HTLV\u2010I\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP), which may be due in part to differences in host immune response to infection. To characterize variations in host immunity across populations, we compared serologic immune marker patterns in HTLV\u2010I\u2010endemic populations in Japan and Jamaica. We matched 204 participants with archived blood from the Miyazaki Cohort Study (Japan) and the Food Handlers Study (Jamaica)\u2014<jats:italic>i.e<\/jats:italic>., 51 HTLV\u2010I\u2010positive (\u201ccarriers\u201d) and 51 HTLV\u2010I\u2010negative individuals (\u201cnoncarriers\u201d) from each population\u2014by age, sex and blood collection year. We compared plasma concentrations of markers of T\u2010cell\u2010mediated (antigen\u2010specific) and nonspecific immunity using regression models and correlation coefficients. Compared to Jamaican HTLV\u2010I noncarriers, Japanese noncarriers had higher covariate\u2010adjusted mean levels of T\u2010cell activation markers, including antibody to Epstein\u2010Barr virus nuclear antigen\u20101 (reciprocal titer 27 <jats:italic>vs<\/jats:italic>. 71, respectively, <jats:italic>p<\/jats:italic> = 0.005), soluble interleukin\u20102 receptor\u2010\u03b1 (477 <jats:italic>vs<\/jats:italic>. 623 pg\/mL, <jats:italic>p<\/jats:italic> = 0.0008) and soluble CD30 (34 <jats:italic>vs<\/jats:italic>. 46 U\/mL, <jats:italic>p<\/jats:italic> = 0.0001) and lower levels of C\u2010reactive protein (1.1 <jats:italic>vs<\/jats:italic>. 0.43 \u03bcg\/mL, <jats:italic>p<\/jats:italic> = 0.0004). HTLV\u2010I infection was associated with activated T\u2010cell immunity in Jamaicans but with diminished T\u2010cell immunity in Japanese persons. The observed population differences in background and HTLV\u2010I\u2010related host immunity correspond closely to the divergent natural histories of infection observed among HTLV\u2010I carriers in Japan and Jamaica and corroborate a role for host immune status in the contrasting patterns of ATL and HAM\/TSP risk. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.24012","type":"journal-article","created":{"date-parts":[[2008,9,19]],"date-time":"2008-09-19T14:07:13Z","timestamp":1221833233000},"page":"614-621","source":"Crossref","is-referenced-by-count":19,"title":["Population differences in immune marker profiles associated with human T\u2010lymphotropic virus type I infection in Japan and Jamaica"],"prefix":"10.1002","volume":"124","author":[{"given":"Brenda M.","family":"Birmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth 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