{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:01:17Z","timestamp":1784127677958,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T00:00:00Z","timestamp":1222214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in equatorial Africa and is linked to Epstein\u2013Barr virus (EBV) and <jats:italic>Plasmodium falciparum<\/jats:italic> coinfections early in life. Epstein\u2013Barr nuclear antigen 1 (EBNA1) is the sole viral latent antigen expressed in BL tumors. Loss of EBNA1\u2010specific immune surveillance could allow eBL emergence. Therefore, EBNA1\u2010specific T cell responses were analyzed by IFN\u2010\u03b3 ELISPOT in Kenyan children with eBL and compared to healthy children with divergent malaria exposure. Significantly fewer children with eBL, 16% (7\/44) had EBNA1\u2010specific IFN\u2010\u03b3 responses in contrast to healthy children living in a malaria holoendemic area or in an area with sporadic malaria transmission, 67% (40\/60) and 72% (43\/60) responders, respectively (<jats:italic>p<\/jats:italic> &lt; 0.003). Children with eBL maintained IgG<jats:sub>1<\/jats:sub> dominated antibody responses to EBNA1 similar to healthy children suggesting a selective loss of IFN\u2010\u03b3 secreting EBNA1\u2010specific T cells in the presence of intact humoral immunity. CD8<jats:sup>+<\/jats:sup> T cell responses to EBV lytic and latent antigens not expressed in the tumors were similarly robust in eBL patients compared to healthy children. In addition, CD4<jats:sup>+<\/jats:sup> T cell responses to a malaria protein, merozoite surface protein 1, were present in lymphoma patients. This study demonstrates a selective loss of EBNA1\u2010specific T cell responses in children with eBL and suggests a potential immunotherapeutic target for this EBV\u2010associated lymphoma. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.24014","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T13:06:25Z","timestamp":1222261585000},"page":"1721-1726","source":"Crossref","is-referenced-by-count":60,"title":["Children with endemic Burkitt lymphoma are deficient in EBNA1\u2010specific IFN\u2010\u03b3 T cell responses"],"prefix":"10.1002","volume":"124","author":[{"given":"Ann M.","family":"Moormann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin N.","family":"Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiprotich","family":"Chelimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Embury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ploutz\u2010Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana A.","family":"Otieno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Oduor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"M\u00fcnz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Rochford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2000.0783"},{"key":"e_1_2_6_3_2","first-page":"S68","article-title":"Burkitt's lymphoma in Kenya: geographical, age, gender and ethnic distribution","author":"Mwanda OW","year":"2004","journal-title":"East Afr Med J"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/511984"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80397-0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/375685a0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088902"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.22.12088-12104.2003"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-023663"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.3.1593"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22179"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.6766-6774.2003"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/428910"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0432"},{"key":"e_1_2_6_15_2","first-page":"165","article-title":"Epstein\u2010Barr virus and Burkitt's lymphoma worldwide: the causal relationship revisited","author":"de\u2010The G","year":"1985","journal-title":"IARC Sci Publ"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031219"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/21900"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-2815.2004.00192.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1300"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.3.1451"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23845"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.24014","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.24014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T09:29:48Z","timestamp":1697448588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.24014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,27]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1002\/ijc.24014"],"URL":"https:\/\/doi.org\/10.1002\/ijc.24014","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,27]]}}}