{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:22:16Z","timestamp":1771064536593,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genetic and environmental factors have been implicated in the etiology of nasopharyngeal carcinoma (NPC), a tumor known to be closely associated with Epstein\u2010Barr virus (EBV) infection. Studies have reported familial aggregation of NPC and have suggested the possible aggregation of NPC and other cancers. We evaluated familial aggregation of cancer in 358 high\u2010risk families with two or more NPC cases enrolled in a NPC genetics study in Taiwan. Participants were linked to the Taiwan National Cancer Registry to identify incident cancers diagnosed after study enrollment (started in 1996) and before December 31, 2005, or death. In total, 2,870 individuals from the NPC Multiplex Family Study contributed 15,151 person\u2010years over an average of 5.3 years of follow\u2010up. One hundred ten incident cancers were identified. Multiple\u2010primary standardized incidence ratios (MP\u2010SIRs) were computed to evaluate overall cancer risk associated with infectious agents and with other tumors. The overall MP\u2010SIR was 1.3 (95% CI: 1.1\u20131.6), which was largely explained by an excess in NPC (MP\u2010SIR = 15; 95% CI: 10\u201323). Exclusion of incident NPC diagnoses led to an overall MP\u2010SIR of 1.0 (95% CI: 0.83\u20131.3). Similarly, the observed excess risk of cancers associated with infectious agents (MP\u2010SIR = 2.0; 95% CI: 1.5\u20132.6) was driven by the excess in NPC; exclusion of NPC cases led to a reduced MP\u2010SIR that did not differ from 1.0. Analysis of the largest NPC multiplex family study to date confirms the presence of coaggregation of NPC within families in Taiwan but does not provide evidence for a broader familial syndrome involving NPC and other tumors. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.24051","type":"journal-article","created":{"date-parts":[[2008,12,9]],"date-time":"2008-12-09T11:05:33Z","timestamp":1228820733000},"page":"1622-1625","source":"Crossref","is-referenced-by-count":25,"title":["Cancer patterns in nasopharyngeal carcinoma multiplex families in Taiwan"],"prefix":"10.1002","volume":"124","author":[{"given":"Kelly J.","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan\u2010Lun","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Ju","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Juen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott R.","family":"Diehl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisa M.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patti E.","family":"Gravitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Hildesheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,27]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Cancer facts and figures 2005","author":"American Cancer Society","year":"2005"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1452"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2001.00449.x"},{"key":"e_1_2_6_5_2","first-page":"1649","article-title":"Human leokocyte antigen (HLA) frequency among patients with nasopharyngeal carcinoma in Taiwan","volume":"9","author":"Wu SB","year":"1989","journal-title":"Anticancer Res"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.16.1207"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.23.1780"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng932"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3253"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910915)68:6<1323::AID-CNCR2820680623>3.0.CO;2-S"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-4208"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20222"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21396"},{"key":"e_1_2_6_14_2","unstructured":"Surveillance Epidemiology and End Results. 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