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Control and c\u2010Met deficient mice were injected with a single dose of N\u2010nitrosodiethylamine (DEN, 90 \u03bcg\/g b.wt.) at 6 weeks of age and mice were subsequently kept on a phenobarbital (PB) containing diet (0.05%) for 35 weeks or on control diet. At the end of the experiment, the carcinogenic response in liver of the animals was monitored. Conditional <jats:italic>c\u2010met<\/jats:italic> knockout (KO) mice showed a higher prevalence of macroscopically visible liver tumours and of glutamine synthetase positive and glucose\u20106\u2010phosphatase deficient lesions in liver. Tumour promotion by PB led to significant increases in the number of preneoplastic and neoplastic lesions in liver of both wild\u2010type and <jats:italic>c\u2010met<\/jats:italic> knockout mice, with only minor differences in response. Our results indicate that a defect in c\u2010Met\u2010mediated signaling increases chemically induced tumour initiation in liver but does not significantly affect PB\u2010mediated tumour promotion. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.24167","type":"journal-article","created":{"date-parts":[[2008,11,19]],"date-time":"2008-11-19T13:50:13Z","timestamp":1227102613000},"page":"1767-1772","source":"Crossref","is-referenced-by-count":21,"title":["Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c\u2010Met"],"prefix":"10.1002","volume":"124","author":[{"given":"Philip","family":"Marx\u2010Stoelting","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malgorzata","family":"Borowiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Knorpp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Birchmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albrecht","family":"Buchmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,12]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1261"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403412101"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2004.09.004"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90564-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1846706"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-05-0106"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.373"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205297"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.18.9577"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204982"},{"key":"e_1_2_6_12_2","first-page":"2064","article-title":"Hepatocyte growth factor induces Wnt\u2010independent nuclear translocation of beta\u2010catenin after Met\u2010beta\u2010catenin dissociation in hepatocytes","volume":"62","author":"Monga SP","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21651"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1905"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh298"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/27.1.13"},{"key":"e_1_2_6_17_2","first-page":"465","article-title":"Application of quantitative stereology to the evaluation of enzyme\u2010altered foci in rat liver","volume":"42","author":"Campbell HA","year":"1982","journal-title":"Cancer Res"},{"key":"e_1_2_6_18_2","unstructured":"R Development Core Team. 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