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Men with parents or siblings affected by lung cancer did not show an increased risk of bladder neoplasms. Among women, the familial association was restricted to daughters of women with lung cancer. Brothers showed higher risks than the sons of bladder cancer patients. Men older than 54 years were at an increased risk of bladder cancer only if their fathers or siblings were diagnosed after age 65 years. The present data indicated a limited contribution of smoking to the familial clustering of bladder cancer with other neoplasms. The dependence of the relative risks on the type of familial relationship probably reflected a heterogeneous character of familial aggregation. Age\u2010specific results suggested differential risk factors for tumors diagnosed before 50 years of age versus neoplasms detected later in life. The present data may guide the design of forthcoming gene identification studies and the interpretation of the genome\u2010wide association studies that are about to be published. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.24178","type":"journal-article","created":{"date-parts":[[2008,11,24]],"date-time":"2008-11-24T17:07:12Z","timestamp":1227546432000},"page":"2166-2171","source":"Crossref","is-referenced-by-count":13,"title":["Sex\u2010specific familial risks of urinary bladder cancer and associated neoplasms in Sweden"],"prefix":"10.1002","volume":"124","author":[{"given":"Justo Lorenzo","family":"Bermejo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Hemminki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,24]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide","author":"Ferlay J","year":"2004"},{"key":"e_1_2_6_3_2","unstructured":"National Board of Health and Welfare.Cancer incidence in Sweden 2006 www.socialstyrelsen.se\/en\/2007."},{"key":"e_1_2_6_4_2","first-page":"1","article-title":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. 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