{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:41:43Z","timestamp":1777110103447,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T00:00:00Z","timestamp":1229990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reasons for higher incidence of lymphoid neoplasms among men than women are unknown. Because female sex hormones have immunomodulatory effects, reproductive factors and exogenous hormone use may affect risk for lymphoid malignancies. Previous epidemiologic studies on this topic have yielded conflicting results. Within the National Institutes of Health\u2010AARP Diet and Health Study cohort, we prospectively analyzed detailed, questionnaire\u2010derived information on menstrual and reproductive factors and use of oral contraceptives and menopausal hormone therapy among 134,074 US women. Using multivariable proportional hazards regression models, we estimated relative risks (RRs) for 85 plasma cell neoplasms and 417 non\u2010Hodgkin lymphomas (NHLs) identified during follow\u2010up from 1996 to 2002. We observed no statistically significant associations between plasma cell neoplasms, NHL, or the 3 most common NHL subtypes and age at menarche, parity, age at first birth, oral contraceptive use or menopausal status at baseline. For menopausal hormone therapy use, overall associations between NHL and unopposed estrogen and estrogen plus progestin were null, with the potential exception of an inverse association (RR = 0.49, 95% CI, 0.25\u20130.96) between use of unopposed estrogen and diffuse large B\u2010cell lymphoma (DLBCL), the most common NHL subtype, among women with a hysterectomy. These data do not support an important role for reproductive factors or exogenous hormones in modulating lymphomagenesis. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.24248","type":"journal-article","created":{"date-parts":[[2008,12,23]],"date-time":"2008-12-23T16:04:27Z","timestamp":1230048267000},"page":"2737-2743","source":"Crossref","is-referenced-by-count":36,"title":["Reproductive factors, exogenous hormone use and risk of lymphoid neoplasms among women in the National Institutes of Health\u2010AARP Diet and Health Study Cohort"],"prefix":"10.1002","volume":"124","author":[{"given":"Lindsay M.","family":"Morton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia S.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas A.","family":"Richesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Schatzkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert R.","family":"Hollenbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"James V.","family":"Lacey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi008"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0001"},{"key":"e_1_2_6_5_2","first-page":"185","article-title":"Late age at first full\u2010term pregnancy as a risk factor for women with malignant lymphoma","volume":"37","author":"Olsson H","year":"1990","journal-title":"Neoplasma"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910550606"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116990"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910620322"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/25.4.737"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.43"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970117)70:2<155::AID-IJC3>3.0.CO;2-W"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(97)00062-3"},{"key":"e_1_2_6_13_2","first-page":"831","article-title":"Childbearing and the risk of Hodgkin's disease","volume":"7","author":"Lambe M","year":"1998","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.5.1381"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014354105164"},{"key":"e_1_2_6_16_2","first-page":"1466","article-title":"Hormone replacement therapy and risk of non\u2010Hodgkin lymphoma and chronic lymphocytic leukemia","volume":"11","author":"Cerhan JR","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025698109991"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11083"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg198"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.cej.0000136573.16740.9c"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000027506.55846.5d"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh278"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-006-9035-8"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603123"},{"key":"e_1_2_6_25_2","first-page":"S89","article-title":"Reproductive factors and hormone use in non\u2010Hodgkin lymphoma (abstract #356)","volume":"165","author":"Lee J","year":"2007","journal-title":"Am J Epidemiol"},{"key":"e_1_2_6_26_2","volume-title":"Proceedings of the Sixth AACR International Conference on Frontiers in Cancer Prevention Research, December 5\u20138, 2007","author":"Prescott J","year":"2007"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn119"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.059"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70434-4"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-119974"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0144"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.12.1119"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj375"},{"key":"e_1_2_6_34_2","first-page":"70","article-title":"Comparison of cancer registry case ascertainment with SEER estimates and self\u2010reporting in a subset of the NIH\u2010AARP Diet and Health Study","volume":"32","author":"Michaud DS","year":"2005","journal-title":"J Regist Manag"},{"key":"e_1_2_6_35_2","volume-title":"International classification of diseases for oncology","author":"Percy C","year":"1990"},{"key":"e_1_2_6_36_2","volume-title":"International Classification of Diseases for Oncology","author":"Fritz A","year":"2000"},{"key":"e_1_2_6_37_2","first-page":"352","volume-title":"World Health Organization classification of tumours","author":"Kleihues P","year":"2001"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-051672"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/68.3.703"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.6.2059"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000036191.79739.98"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.24248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.24248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T17:11:49Z","timestamp":1699895509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.24248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,25]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1002\/ijc.24248"],"URL":"https:\/\/doi.org\/10.1002\/ijc.24248","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,25]]}}}