{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:37:32Z","timestamp":1790264252549,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T00:00:00Z","timestamp":1232582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A family history of colorectal cancer may increase colorectal cancer risk by influencing adenoma growth or enhancing the formation of new lesions. Data of men from the prospective Health Professionals Follow\u2010Up Study who underwent an endoscopy between 1986 and 2004 were used to evaluate whether a family history of colorectal cancer is associated with adenoma multiplicity or advanced adenoma stage (\u22651 cm, histology with villous component or carcinoma <jats:italic>in situ<\/jats:italic>). 21.4% of the 3,881 adenoma patients and 13.9% of the 24,959 adenoma\u2010free men had a first\u2010degree relative with colorectal cancer. Thousand four hundred and ninety\u2010six men were classified as having advanced and 1,507 as having nonadvanced adenomas. Six hundred and twenty\u2010two men had multiple and 1,985 had single adenomas in the distal colon and rectum. A family history of colorectal cancer was similarly associated with advanced and nonadvanced adenomas [multivariable odds ratio (OR) (95% confidence interval): advanced <jats:italic>vs<\/jats:italic>. nonadvanced, 0.98 (0.82\u20131.17), advanced <jats:italic>vs<\/jats:italic>. adenoma\u2010free: 1.67 (1.47\u20131.91), nonadvanced <jats:italic>vs<\/jats:italic>. adenoma\u2010free: 1.70 (1.49\u20131.94)], although potential differences according to adenoma location were seen. A family history of colorectal cancer was more strongly associated with multiple distally located adenomas [odds ratio (95% confidence interval): multiple <jats:italic>vs<\/jats:italic>. single, 1.35 (1.09\u20131.68), multiple <jats:italic>vs<\/jats:italic>. no distally located adenomas: 2.02 (1.67\u20132.44), single <jats:italic>vs<\/jats:italic>. no distally located adenomas: 1.49 (1.32\u20131.68)]. The number of adenomas was also positively associated with a family history of colorectal cancer. Our findings suggest that at the population level, heritable factors may be more important in earlier stages of adenoma formation than at stages of adenoma advancement for at least distally located adenomas. \u00a9 2009 UICC<\/jats:p>","DOI":"10.1002\/ijc.24288","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T20:11:00Z","timestamp":1232655060000},"page":"413-420","source":"Crossref","is-referenced-by-count":34,"title":["Family history of colorectal cancer: A determinant of advanced adenoma stage or adenoma multiplicity?"],"prefix":"10.1002","volume":"125","author":[{"given":"Petra A.","family":"Wark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"van 't 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