{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:07:45Z","timestamp":1792688865240,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T00:00:00Z","timestamp":1237420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Antigenic targets of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) paraproteins might play a role in the pathogenesis of these neoplasms. We screened a human fetal brain\u2010derived macroarray with the IgA or IgG containing sera of 192 consecutive MGUS and MM patients. Twenty\u2010nine of 192 (15.1%) paraproteins reacted with paratarg\u20107, a protein of unknown function which is expressed in all human tissues. Paratarg\u20107 reactivity was similarly frequent among IgA and IgG paraproteins, but all paratarg\u20107 reactive IgG paraproteins belonged to the IgG3 subtype with 24\/57 IgG3 (42.1%) paraproteins displaying this specificity. Sequence analysis of paratarg\u20107 derived from patients having a paraprotein with specificity for paratarg\u20107 revealed no differences to paratarg\u20107 derived from patients with paraproteins of other specificities or healthy controls, excluding mutations or polymorphisms as a reason for its autoimmunogenicity. Similarly, Western\u2010blot analysis showed identical bands for paratarg\u20107 derived from patients and controls. The above\u2010random frequency of paratarg\u20107 as a paraprotein target suggests that paratarg\u20107 might be involved in the development of the respective clonal proliferations. The identification of paratarg\u20107 as an antigenic target enables the more detailed analysis of tumor\u2013host interactions in these patients and their role in the pathogenesis of MM and MGUS. \u00a9 2009 UICC<\/jats:p>","DOI":"10.1002\/ijc.24427","type":"journal-article","created":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T13:14:16Z","timestamp":1237468456000},"page":"656-661","source":"Crossref","is-referenced-by-count":41,"title":["A frequent target of paraproteins in the sera of patients with multiple myeloma and MGUS"],"prefix":"10.1002","volume":"125","author":[{"given":"Klaus\u2010Dieter","family":"Preuss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pfreundschuh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Ahlgrimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Fadle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evi","family":"Regitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Murawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Grass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,29]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.18.8482"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.3.525"},{"key":"e_1_2_5_4_2","first-page":"163","article-title":"Antibody 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