{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:32:59Z","timestamp":1768311179874,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T00:00:00Z","timestamp":1237420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prostate, breast and lung cancers readily develop bone metastases which lead to fractures, hypercalcemia and pain. Malignant growth in the bones depends on osteoclast\u2010mediated bone resorption and in this regard bisphosphonate compounds, which have high\u2010bone affinity and inhibit osteoclast activity, have been found to alleviate bone cancer symptoms. In this study, the bisphosphonate risedronate and its phosphonocarboxylate derivative NE\u201010790 was tested in a murine bone cancer pain model. Risedronate decreased bone cancer\u2010related bone destruction and pain\u2010related behavior and decreased the spinal expression of glial fibrillary acidic protein, whereas NE\u201010790 had no effect on these parameters. Furthermore, risedronate but not NE\u201010790 induced dose\u2010dependent toxicity in NCTC\u20102472 cells <jats:italic>in vitro<\/jats:italic>. Furthermore, the direct toxic effect of risedronate on tumor cells observed <jats:italic>in vitro<\/jats:italic> opens the possibility that a direct toxic effect on tumor cells may also be present <jats:italic>in vivo<\/jats:italic> and be related to the efficacy of bisphosphonate compounds. In conclusion, these results suggest that risedronate treatment may lead to an increased life quality, in patient suffering from bone cancer, in terms of decreased osteolysis and pain, and merits further study. \u00a9 2009 UICC<\/jats:p>","DOI":"10.1002\/ijc.24436","type":"journal-article","created":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T13:18:27Z","timestamp":1237468707000},"page":"1177-1185","source":"Crossref","is-referenced-by-count":19,"title":["Cancer\u2010induced bone loss and associated pain\u2010related behavior is reduced by risedronate but not its phosphonocarboxylate analog NE\u201010790"],"prefix":"10.1002","volume":"125","author":[{"given":"Andreas","family":"Hald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikke R.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette 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