{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:23:57Z","timestamp":1790429037387,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T00:00:00Z","timestamp":1237420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The potential introduction of the newly licensed HPV\u2010vaccines at affordable prices could play a central role in preventing cervical cancer in middle and low\u2010income countries, where most of the cases occur. In spite of this, basic epidemiological data about HPV and HPV\u2010related lesions are still scarce. To determine the prevalence of cervical abnormalities, HPV prevalence, genotype distribution and related risk factors, we carried out a cross\u2010sectional study in a population from Guatemala that included 297 women from the general population (GP women) and 297 sex workers (SW). All participating women were interviewed and underwent a complete gynecological examination that included collection of cervical cells for cytological diagnosis, HPV DNA detection and typing by PCR methods. Cervical HPV DNA prevalence among GP women and from SW was 38.1% (95% CI: 32.5\u201343.8) and 67.3% (95% CI: 61.7\u201372.6), respectively. The prevalence of abnormal cytology among GP women was 7.7% (ASCUS = 1.4%, LSIL = 4.7%, ASC\u2010H = 0.3% and HSIL = 1.4%) and among SW was 21.6% (ASCUS = 7.5%, LSIL = 10.6%, ASC\u2010H = 1.4% and HSIL = 2.1%). The most prevalent HPV types among women with normal cytology were HPVs 51 (<jats:italic>n<\/jats:italic> = 30), 66 (<jats:italic>n<\/jats:italic> = 25) and 16 (<jats:italic>n<\/jats:italic> = 25), and among women with HSIL or ASC\u2010H (<jats:italic>n<\/jats:italic> = 14) HPVs 58 (<jats:italic>n<\/jats:italic> = 5) and 16 (<jats:italic>n<\/jats:italic> = 5). Determinants associated with HPV DNA detection were having had an occasional partner during the last 6 months and smoking habit among GP women, and being a minor among SW. HPV and abnormal cytology prevalence is high among women in Guatemala. The introduction of a HPV vaccination program would prevent an important fraction of HPV\u2010related disease burden. \u00a9 2009 UICC<\/jats:p>","DOI":"10.1002\/ijc.24444","type":"journal-article","created":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T13:14:32Z","timestamp":1237468472000},"page":"1161-1167","source":"Crossref","is-referenced-by-count":23,"title":["High prevalence of human papillomavirus infection in the female population of Guatemala"],"prefix":"10.1002","volume":"125","author":[{"given":"Xavier","family":"Vall\u00e8s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys Beatriz","family":"Murga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Sabid\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Chuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Lloveras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Alameda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia","family":"de San Jos\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc Xavier","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Pedroza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Castellsagu\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Casabona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,5,4]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Globocan 2002: cancer incidence, mortality and prevalence worldwide iarc cancer. Base No 5, Version 2.0","author":"Ferlay F","year":"2004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a003479"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.05.064"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22527"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60946-5"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061760"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23260"},{"key":"e_1_2_6_11_2","unstructured":"National STI\/HIV\/AIDS Programme UNGASS Commitment Progress Report. UNAIDS.2006."},{"key":"e_1_2_6_12_2","article-title":"The UALE Project: decline in the incidence of HIV and sexually transmitted infections and increase in the use of condoms among sex workers in Guatemala","author":"Sabid\u00f3 M","year":"2009","journal-title":"JAIDS"},{"key":"e_1_2_6_13_2","first-page":"2140","article-title":"The 2001 Bethesda system: terminology for reporting results of cervical cytology","volume":"287","author":"Solomon D","year":"2001","journal-title":"JAMA"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.3.902-907.2002"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-3-7"},{"key":"e_1_2_6_16_2","first-page":"350","article-title":"Prevalence of human papillomavirus and Herpes Virus Type 2 infection in Korean commercial sex workers","volume":"18","author":"Yun H","year":"2008","journal-title":"J Microbiol Biotechnol"},{"key":"e_1_2_6_17_2","first-page":"393","article-title":"Prevalence of HPV in sex workers in Durango, Mexico","volume":"47","author":"Rodriguez\u2010Reyes ER","year":"2005","journal-title":"Salud Pulbica Mex"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1071\/SH05019"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.4.1428-1434.2006"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603252"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70158-5"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/428850"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22241"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(02)00188-0"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/514052"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0577"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600442"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053284"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-36342003000900008"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2904"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e318164e567"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02438-06"},{"key":"e_1_2_6_33_2","first-page":"3939","article-title":"Comparison of DNA sequencing and Roche Linear array in human papillomavirus (HPV) genotyping","volume":"26","author":"Giuliani L","year":"2006","journal-title":"Anticancer Res"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/87.11.796"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.24444","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.24444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T11:18:35Z","timestamp":1696936715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.24444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,4]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1002\/ijc.24444"],"URL":"https:\/\/doi.org\/10.1002\/ijc.24444","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,4]]}}}