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A number of genes upregulated in colorectal cancer cells compared to normal colorectal epithelial cells were identified including <jats:italic>STC2<\/jats:italic>. <jats:italic>STC2<\/jats:italic> gene expression in cancer tissue was higher than in corresponding normal colorectal epithelial tissue in 124 of 139 cases (89.2%, <jats:italic>p<\/jats:italic> &lt; 0.01). Tumors with high <jats:italic>STC2<\/jats:italic> expression showed higher frequencies of lymph node metastasis, lymphatic invasion, tumor depth, tumor size and AJCC Stage classification (<jats:italic>p<\/jats:italic> &lt; 0.01). Patients with high <jats:italic>STC2<\/jats:italic> expression also showed significantly worse overall survival rates than those with low <jats:italic>STC2<\/jats:italic> expression (<jats:italic>p<\/jats:italic> &lt; 0.01). Furthermore, <jats:italic>STC2<\/jats:italic> gene appeared to be associated with colorectal cancer progression and may be a useful prognostic indicator for colorectal cancer. \u00a9 2009 UICC<\/jats:p>","DOI":"10.1002\/ijc.24453","type":"journal-article","created":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T12:24:46Z","timestamp":1237983886000},"page":"926-931","source":"Crossref","is-referenced-by-count":50,"title":["Clinicopathological significance of <i>stanniocalcin 2<\/i> gene expression in colorectal 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