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In Epstein\u2010Barr virus (EBV)\u2010associated cases of cHL, expression of viral antigens most probably leads to NF\u2010\u03baB activation but for non\u2010EBV\u2010associated cases, the mechanism is not clear. Previous small studies have demonstrated deleterious mutations of <jats:italic>NFKBIA<\/jats:italic>, the gene encoding I\u03baB\u03b1, in HRS cells. In the present study, we aimed to establish the frequency of <jats:italic>NFKBIA<\/jats:italic> mutation in cHL by investigating a larger series of cases and to determine whether these mutations are a characteristic feature of non\u2010EBV\u2010associated cHL. Single HRS cells from 20 cases of cHL were analysed by PCRs covering all 6 exons of the gene. Clonal deleterious mutations were detected in 3 cases and in 1 case both alleles of the gene were shown to harbour mutations. <jats:italic>NFKBIA<\/jats:italic> mutations were detected only in non\u2010EBV\u2010associated cases but the majority of these cases had wild\u2010type <jats:italic>NFKBIA<\/jats:italic>. It remains possible that defects in genes encoding other inhibitors of NF\u2010\u03baB, such as TNFAIP3 (A20) and CYLD, are involved in the latter cases, as described for one case in this series. \u00a9 2009 UICC<\/jats:p>","DOI":"10.1002\/ijc.24502","type":"journal-article","created":{"date-parts":[[2009,4,13]],"date-time":"2009-04-13T13:27:05Z","timestamp":1239629225000},"page":"1334-1342","source":"Crossref","is-referenced-by-count":78,"title":["Mutations of <i>NFKBIA<\/i>, encoding I\u03baB\u03b1, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non\u2010EBV\u2010associated cases"],"prefix":"10.1002","volume":"125","author":[{"given":"Annette","family":"Lake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley A.","family":"Shield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Cordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.Y.","family":"Chui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Osborne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shauna","family":"Crae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Tosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J.L.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Gesk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiner","family":"Siebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron T.","family":"Hay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth F.","family":"Jarrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,14]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.10.4340.bloodjournal87104340"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119849"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1128"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209954"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00477-X"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00375.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62578-3"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021279"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031080"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400765101"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209934"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209937"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.110.3.369"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340170405"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81699-2"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81698-0"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.2.872"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111559200"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90511-1"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.16.5.2341"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02794"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01645-7"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.11.092"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01811"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01802"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01803"},{"key":"e_1_2_6_28_2","doi-asserted-by":"crossref","first-page":"17971","DOI":"10.1016\/S0021-9258(19)37138-8","article-title":"Transcriptional activation of the tumor necrosis factor alpha\u2010inducible zinc finger protein. 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