{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:48:36Z","timestamp":1761630516566},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:00:00Z","timestamp":1239667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A case\u2010control study was conducted in 140 people with histology proven cutaneous squamous cell carcinoma (SCC) and 454 controls, nested within 2 cohorts of organ transplant recipients (OTR) recruited in London and Oxford between 2002 and 2006. All participants had a skin examination, completed a questionnaire and had serum tested for antibodies against the L1 antigen of 34 HPV types using Luminex technology. SCC was more common in men than women (odds ratio [OR] = 1.7, 95% confidence interval [CI]: 1.1\u20132.8, <jats:italic>p<\/jats:italic> = 0.02) and in people with susceptibility to burn easily (OR = 3.0, 95%CI: 1.9\u20134.8; <jats:italic>p<\/jats:italic> &lt; 0.001). The risk increased with increasing age (<jats:italic>p<\/jats:italic>\u2010trend &lt; 0.001), increasing time since transplant (<jats:italic>p<\/jats:italic>\u2010trend &lt; 0.001), increasing self\u2010reported number of sunburns as a child (<jats:italic>p<\/jats:italic>\u2010trend &lt; 0.001) and with the presence of viral warts (<jats:italic>p<\/jats:italic> &lt; 0.001). As expected, antibodies against HPV 16 were associated with a self\u2010reported history of an abnormal cervical smear among women (OR 5.1, 95%CI: 2.6\u201310.2) and antibodies against HPV 6 were associated with a self\u2010reported history of genital warts (OR 4.0, 95%CI: 2.2\u20137.2). However, no clear associations between any of the HPV types examined (including cutaneous betaHPVs) and SCC were identified. For example, the seroprevalence of HPV 5 was 15% among cases and 9% among controls (<jats:italic>p<\/jats:italic> = 0.09) and the seroprevalence of HPV 8 was 23% among cases and 21% among controls (<jats:italic>p<\/jats:italic> = 0.6). Nor was seropositivity to multiple types associated with SCC. These serological data do not provide evidence for a role for HPV in the aetiology of cutaneous SCC among OTR in two UK\u2010based populations. \u00a9 2009 UICC<\/jats:p>","DOI":"10.1002\/ijc.24511","type":"journal-article","created":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T17:57:51Z","timestamp":1239731871000},"page":"1935-1945","source":"Crossref","is-referenced-by-count":20,"title":["A case\u2010control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: The role of antibodies against human papillomavirus and other risk 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