{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:25:36Z","timestamp":1758122736131},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T00:00:00Z","timestamp":1240358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A recent whole\u2010genome association study identified a strong association between polymorphisms in the prostate stem cell antigen (PSCA) gene and stomach cancer risk. In this case\u2010control study, we aimed to validate this association, and further to explore environmental factors possibly interacting with <jats:italic>PSCA<\/jats:italic> polymorphisms in 708 incident stomach cancer cases and 708 age\u2013sex matched controls. The association between <jats:italic>PSCA<\/jats:italic> polymorphisms and <jats:italic>Helicobacter pylori<\/jats:italic> infection was also examined. We found that rs2294008 and rs2976392, which were strongly linked to each other (<jats:italic>D<\/jats:italic>\u2032 = 1.00), were significantly associated with stomach cancer risk. Per allele odds ratio for rs2994008 was 1.40 (95% confidence interval: 1.19\u20131.65; <jats:italic>p<\/jats:italic> = 3.7 \u00d7 10<jats:sup>\u22125<\/jats:sup>). We found significant interaction with a family history of stomach cancer in first\u2010degree relatives (<jats:italic>p<\/jats:italic>\u2010heterogeneity = 0.009). Similar to originally reported association, we found significant heterogeneity between diffuse and intestinal type (<jats:italic>p<\/jats:italic>\u2010heterogeneity = 0.007). No association was seen between <jats:italic>PSCA<\/jats:italic> polymorphisms and <jats:italic>H. pylori<\/jats:italic> infection. In conclusion, <jats:italic>PSCA<\/jats:italic> polymorphisms are associated with stomach cancer risk in Japanese. A possible interaction with family history warrants further evaluation. \u00a9 2009 UICC<\/jats:p>","DOI":"10.1002\/ijc.24519","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T12:29:08Z","timestamp":1240403348000},"page":"1961-1964","source":"Crossref","is-referenced-by-count":54,"title":["Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in Japanese"],"prefix":"10.1002","volume":"125","author":[{"given":"Keitaro","family":"Matsuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takakazu","family":"Kawase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Shitara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Misawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Sawaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Muro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneya","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Yamao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Yamamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Hamajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Hiraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,7,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hym112"},{"key":"e_1_2_6_3_2","volume-title":"The global burden of disease: 2004 Update","author":"WHO","year":"2008"},{"key":"e_1_2_6_4_2","series-title":"Schstosomes, liver flukes and Helicobacter pylori. 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