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We conducted a nested case\u2010control study on 973 CxCa cases and 1,763 matched controls, from two Swedish population\u2010based cohorts to examine the association of common genetic variants with CxCa risk. Human leukocyte antigen (HLA) alleles and 24 other polymorphisms in 14 genes were selected on the basis of reported association or mechanistic plausibility with an HPV infection or cervical cancer development. Genotyping was conducted using multiplex PCR and Luminex technology. A significant association of CxCa with various polymorphisms was observed: rs1800797 in the <jats:italic>IL\u20106<\/jats:italic> gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79\u20130.99); rs1041981 in the <jats:italic>LTA<\/jats:italic> gene (OR = 0.87, 95% CI: 0.78\u20130.98), and rs9344 in the <jats:italic>CCND1<\/jats:italic> gene (OR = 1.14, 95% CI: 1.02\u20131.27), for those individuals carrying the rare allele. Additionally, the alleles 0401 and 1501 of the HLA class II DRB1 locus were associated with an increased risk (OR = 1.23, 95% CI: 1.04\u20131.45 and OR = 1.29, 95% CI: 1.11\u20131.50, respectively), and allele 1301 was associated with decreased risk (OR = 0.59, 95% CI: 0.47\u20130.73). The effects of <jats:italic>CCND1<\/jats:italic> and the HLA*DRB1 alleles were independent of the effect of smoking. We did not find any association of risk with polymorphisms in genes related to the innate immune system. In conclusion, our study provides evidence for genetic susceptibility to CxCa due to variations in genes involved in the immune system and in cell cycle. \u00a9 2009 UICC<\/jats:p>","DOI":"10.1002\/ijc.24529","type":"journal-article","created":{"date-parts":[[2009,7,7]],"date-time":"2009-07-07T14:51:47Z","timestamp":1246978307000},"page":"1851-1858","source":"Crossref","is-referenced-by-count":73,"title":["Association of HLA\u2010DRB1, interleukin\u20106 and cyclin D1 polymorphisms with cervical cancer in the Swedish population\u2014A candidate gene approach"],"prefix":"10.1002","volume":"125","author":[{"given":"Felipe 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