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Between the 1984\u201386 and 1999\u201301 periods, the age\u2010adjusted incidence rate of all first primary cancers of the UADT decreased from 11.6 (11.2\u201312.0) to 8.8 (8.5\u20139.1) in Ontario and 13.0 (12.7\u201313.3) to 10.2 (10.0\u201310.4) in the US. Significant decreases in incidence were observed in many UADT sites but there was no significant change in the incidence of cancer of the oropharynx in either the US or Canada. Over the same period, the 5\u2010year relative survival for all UADT cancers increased from 49.2% (47.2\u201351.2%) to 57.1%(55.0\u201359.1%) in Ontario and from 48.1% (46.9\u201349.3%) to 52.4% (51.2\u201353.6%) in the US. This significant improvement in the outcome of UADT cancer was largely due to a dramatic increase in the 5\u2010year relative survival for cancers of the oropharynx from 31.1% (27.1\u201335.1%) to 53.6% (49.3\u201357.9%) in Ontario and from 35.3% (32.9\u201337.8%) to 51.0% (48.7\u201353.3%) in the US. Smaller increases in survival were observed in cancers of the oral cavity, nasopharynx, and hypopharynx, but there was no evidence of any increase in survival for cancer of the larynx. These results are consistent with the hypothesis that there has been a major change in the etiology of cancer of the oropharynx in Canada and the US and a concomitant change in its response to therapy. \u00a9 2009 UICC<\/jats:p>","DOI":"10.1002\/ijc.24533","type":"journal-article","created":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T12:20:22Z","timestamp":1246364422000},"page":"2159-2165","source":"Crossref","is-referenced-by-count":121,"title":["Temporal trends in the incidence and survival of cancers of the upper aerodigestive tract in Ontario and the United States"],"prefix":"10.1002","volume":"125","author":[{"given":"Shlok","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Mackillop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,6,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/CA.2007.0010"},{"key":"e_1_2_6_3_2","first-page":"3282","article-title":"Smoking and drinking in relation to oral and pharyngeal cancer","volume":"48","author":"Blot WJ","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22963"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.1713"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.709"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.09.011"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065497"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn011"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31813e5fbb"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1728::AID-CNCR29>3.0.CO;2-7"},{"key":"e_1_2_6_12_2","first-page":"31","article-title":"Smoking prevalence, quit attempts and successes","volume":"9","author":"Stephens M","year":"1998","journal-title":"Health Rep"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22851"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20740"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000236095.97947.26"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.24.2081"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.4.1318"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.7.1458"},{"key":"e_1_2_6_19_2","volume-title":"SEER cancer statistics review, 1975\u20102005","author":"NCI","year":"2008"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(88)90052-2"},{"key":"e_1_2_6_21_2","first-page":"246","volume-title":"Cancer registration principles and methods","author":"Clarke EA","year":"1991"},{"key":"e_1_2_6_22_2","volume-title":"The international statistical classification of diseases and health related problems, ICD\u201010","author":"WHO","year":"2004"},{"key":"e_1_2_6_23_2","volume-title":"International classification of diseases for oncology, ICD\u2010O","author":"Fritz AG","year":"2000"},{"key":"e_1_2_6_24_2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/9780470773666","volume-title":"Statistical methods in medical research","author":"Armitage D","year":"2002"},{"key":"e_1_2_6_25_2","first-page":"101","article-title":"The relative survival rate: a statistical methodology","volume":"6","author":"Ederer F","year":"1961","journal-title":"NCI Monogr"},{"key":"e_1_2_6_26_2","unstructured":"NCI.SEER Summary Staging Manual 2000: Codes and Coding Instructions. 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