{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:54:41Z","timestamp":1791125681684,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,5,18]],"date-time":"2009-05-18T00:00:00Z","timestamp":1242604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Second primary neoplasms (SPNs) are a recognised late effect of treatment for childhood cancer. Thyroid SPNs can develop after exposure to low\u2010dose radiation, due to the radio\u2010sensitivity of the thyroid gland. The British Childhood Cancer Survivor Study (BCCSS) was set up to directly monitor the late effects of treatment, including risk of SPNs, in childhood cancer survivors and includes 17,980 5\u2010year survivors. We carried out a cohort analysis to determine the risk of thyroid SPNs in the BCCSS, and estimated risk using standardised incidence ratios (SIRs), relative risk (RR) using multivariate Poisson regression and cumulative incidence curves. There were 340,202 person years at risk subsequent to a 5\u2010year survival, median follow\u2010up 17.4 years per survivor. We identified 50 thyroid SPNs including 31 (62%) papillary carcinomas, 15 (30%) follicular carcinomas and 4 (8%) other types. 88% of thyroid SPNs developed after exposure to radiotherapy in or around the thyroid gland. SIR overall was 18.0 (95% confidence interval 13.4\u201323.8). Risk of thyroid cancer was highest after Hodgkin's disease: RR 3.3 (1.1\u201310.1) and Non Hodgkin's Lymphoma: RR 3.4 (1.1\u201310.7) relative to leukaemia (RR 1.0) (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Survivors treated with radiotherapy in childhood had a RR of 4.6 (1.4\u201315.1) relative to survivors not treated with radiotherapy (RR 1.0),\n                    <jats:italic>p<\/jats:italic>\n                    = 0003. In conclusion, the risk of thyroid cancer in childhood cancer survivors is relatively high in this cohort of childhood cancer survivors. These results will be of use in counselling survivors of childhood cancer exposed to radiation in or around the thyroid area. \u00a9 2009 UICC\n                  <\/jats:p>","DOI":"10.1002\/ijc.24581","type":"journal-article","created":{"date-parts":[[2009,5,18]],"date-time":"2009-05-18T11:55:27Z","timestamp":1242647727000},"page":"2400-2405","source":"Crossref","is-referenced-by-count":93,"title":["Risk of thyroid cancer in survivors of childhood cancer: Results from the British Childhood Cancer Survivor Study"],"prefix":"10.1002","volume":"125","author":[{"given":"Aliki J.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P.","family":"Croft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee M.","family":"Palace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul C.","family":"Reulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Stiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.G.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike M.","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,9,18]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"63","volume-title":"Cancer Stats Monograph 2004","author":"Kroll ME","year":"2004"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.63.1.23"},{"key":"e_1_2_6_4_2","unstructured":"Cancer Research UK. Childhood cancer: UK childhood cancer statistics. Available at:http:\/\/info.cancerresearchuk.org\/cancerstats\/childhoodcancer\/?a=5441. Accessed February 18 2009."},{"key":"e_1_2_6_5_2","volume-title":"Childhood cancer survivorship: improving care and quality of life","author":"Hewitt M","year":"2003"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602226"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.09.020"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1667\/RR3233"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji151"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.9.1060"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66695-0"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690300"},{"key":"e_1_2_6_13_2","first-page":"2885","article-title":"Therapeutic radiation at a young age is linked to secondary thyroid cancer. The Late Effects Study Group","volume":"51","author":"Tucker MA","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11362"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21335"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470870709"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602102"},{"key":"e_1_2_6_19_2","unstructured":"Cancer Research UK. Cancer stats: thyroid cancer: Thyroid cancer survival statistics. Available at:http:\/\/info.cancerresearchuk.org\/cancerstats\/types\/thyroid\/survival\/. Accessed February 18 2009."},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.8.618"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6911.1030"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22827"},{"key":"e_1_2_6_23_2","unstructured":"Cancer Research UK. Cancer stats. Thyroid Cancer: UK thyroid cancer incidence statistics. Available at:http:\/\/info.cancerresearchuk.org\/cancerstats\/types\/thyroid\/incidence\/?a=5441. Accessed February 18 2009."},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1132"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115743"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0293"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.06.005"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2008.05.001"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.10.019"},{"key":"e_1_2_6_30_2","unstructured":"United Kingdom Children's Cancer Study Group. Late effects group practice statement. Therapy based long term follow up (Thyroid). Second edition 2005. Available at:http:\/\/www.ukccsg.org\/public\/followup\/PracticeStatement\/10.pdf. Accessed February 18 2009."},{"key":"e_1_2_6_31_2","unstructured":"Children's Oncology Group. Long\u2010term follow\u2010up guidelines for survivors of childhood adolescent and young adult cancers. Available at:http:\/\/www.survivorshipguidelines.org\/pdf\/LTFUGuidelines.pdf. Accessed February 18 2009."}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.24581","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.24581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T18:52:26Z","timestamp":1695927146000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.24581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,18]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2009,11,15]]}},"alternative-id":["10.1002\/ijc.24581"],"URL":"https:\/\/doi.org\/10.1002\/ijc.24581","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,18]]}}}