{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T22:49:19Z","timestamp":1794610159818,"version":"4.9.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T00:00:00Z","timestamp":1245024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2010,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endemic, sporadic and HIV\u2010associated Burkitt lymphoma (BL) all have a B\u2010cell phenotype and a <jats:italic>MYC<\/jats:italic> translocation, but a variable association with the Epstein\u2010Barr virus (EBV). However, there is still no satisfactory explanation of how EBV participates in the pathogenesis of BL. A recent investigation suggested that EBV\u2010positive and EBV\u2010negative BL have different cells of origin. In particular, according to immunoglobulin gene mutation analysis, EBV\u2010negative BLs may originate from early centroblasts, whereas EBV\u2010positive BLs seem to arise from postgerminal center B cells or memory B cells. The appearance of a germinal center phenotype in EBV\u2010positive cells might thus derive from a block in B\u2010cell differentiation. The exit from the germinal center involves a complex series of events, which require the activation of BLIMP\u20101, and the consequent downregulation of several target genes. Here, we investigated the expression of specific miRNAs predicted to be involved in B\u2010cell differentiation and found that hsa\u2010miR\u2010127 is differentially expressed between EBV\u2010positive and EBV\u2010negative BLs. In particular, it was strongly upregulated only in EBV\u2010positive BL samples, whereas EBV\u2010negative cases showed levels of expression similar to normal controls, including microdissected germinal centers (GC) cells. In addition, we found evidence that hsa\u2010miR\u2010127 is involved in B\u2010cell differentiation process through posttranscriptional regulation of BLIMP1 and XBP1. The overexpression of this miRNA may thus represent a key event in the lymphomagenesis of EBV positive BL, by blocking the B\u2010cell differentiation process.<\/jats:p>","DOI":"10.1002\/ijc.24655","type":"journal-article","created":{"date-parts":[[2009,6,15]],"date-time":"2009-06-15T19:07:18Z","timestamp":1245092838000},"page":"1316-1326","source":"Crossref","is-referenced-by-count":61,"title":["B\u2010cell differentiation in EBV\u2010positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA\u2010altered expression"],"prefix":"10.1002","volume":"126","author":[{"given":"Eleonora","family":"Leucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Onnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Cocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"De 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