{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:44:28Z","timestamp":1792028668438,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T00:00:00Z","timestamp":1245369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2009,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T\u2010lymphotropic virus type 1 (HTLV\u20101) is the causative agent of adult T\u2010cell leukemia\/lymphoma (ATLL). It has been postulated that ATLL cells might act as regulatory T cells (T<jats:sub>regs<\/jats:sub>) which, in common with ATLL cells, express both CD25 and FoxP3, and so contribute to the severe immune suppression typical of ATLL. We report here that the frequency of CD25<jats:sup>+<\/jats:sup> cells varied independently of the frequency of FoxP3<jats:sup>+<\/jats:sup> cells in both a cross\u2010sectional study and in a longitudinal study of 2 patients with chronic ATLL. Furthermore, the capacity of ATLL cells to suppress proliferation of heterologous CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>\u2212<\/jats:sup> cells correlated with the frequency of CD4<jats:sup>+<\/jats:sup> FoxP3<jats:sup>+<\/jats:sup> cells but was independent of CD25 expression. Finally, the frequency of CD4<jats:sup>+<\/jats:sup>FoxP3<jats:sup>+<\/jats:sup> cells was inversely correlated with the lytic activity of HTLV\u20101\u2010specific CTLs in patients with ATLL. We conclude that ATLL is not a tumor of FoxP3<jats:sup>+<\/jats:sup> regulatory T cells, and that a population of FoxP3<jats:sup>+<\/jats:sup> cells distinct from ATLL cells has regulatory functions and may impair the cell\u2010mediated immune response to HTLV\u20101 in patients with ATLL. \u00a9 2009 UICC<\/jats:p>","DOI":"10.1002\/ijc.24664","type":"journal-article","created":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T18:05:02Z","timestamp":1245434702000},"page":"2375-2382","source":"Crossref","is-referenced-by-count":63,"title":["FoxP3<sup>+<\/sup> regulatory T cells are distinct from leukemia cells in HTLV\u20101\u2013associated adult T\u2010cell leukemia"],"prefix":"10.1002","volume":"125","author":[{"given":"Frederic","family":"Toulza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisato","family":"Nosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Takiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Pagliuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Mitsuya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuetsu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham P.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles 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