{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:01:42Z","timestamp":1760346102626,"version":"3.37.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,7,7]],"date-time":"2009-07-07T00:00:00Z","timestamp":1246924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After treatment of the cervical intraepithelial neoplasia (CIN) cervical cancer incidence remains elevated at least for 20 years. Whether the overall or cervical cancer mortality after treatment of CIN is elevated is unknown. The aim of this study was to determine the long\u2010term survival and cause\u2010specific mortality among women treated for CIN. The study population consisted of 7,104 women treated for CIN between 1974 and 2001 and 35,437 individually matched controls. The follow\u2010up of mortality was based on nationwide registries and closed at death, emigration or December 31, 2005. The possible differences in mortality were assessed using Cox proportional hazard model. With follow\u2010up time of approximately 630,000 woman\u2010years, overall 2,781 deaths were observed, 530 among women treated for CIN and 2,251 among reference population (HR 1.1, 95% CI 1.0\u20131.3). Mortality from any cancer (HR 1.4, 95% CI 1.2\u20131.7), lung cancer (HR 2.7, 95% CI 1.8\u20134.1) and HPV\u2010related anogenital cancer (HR 3.1, 95% CI 1.1\u20138.6) was higher among CIN patients, but mortality from cervical cancer was not (HR 1.0, 95% CI 0.3\u20134.0). Elevated cervical cancer incidence after treatment of CIN, documented earlier, did not predict elevation in cervical cancer mortality. This suggests high effectiveness of CIN management. Most of the excess mortality observed among CIN patients was due to increased risk of other cancers. These long\u2010term mortality patterns should be considered when planning and evaluating the management of CIN lesions and related cervical or other cancer prevention activity.<\/jats:p>","DOI":"10.1002\/ijc.24713","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T11:53:03Z","timestamp":1247140383000},"page":"224-231","source":"Crossref","is-referenced-by-count":11,"title":["Mortality in a long\u2010term follow\u2010up after treatment of CIN"],"prefix":"10.1002","volume":"126","author":[{"given":"Ilkka","family":"Kalliala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Dyba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pekka","family":"Nieminen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Hakulinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahti","family":"Anttila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,13]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"IARC Screening group[Internet]. Lyon France: International Agency for Research on Cancer; c2009. Cervical cancer;2009. Available at:http:\/\/screening.iarc.fr\/cervicalindex.php."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990924)83:1<59::AID-IJC12>3.0.CO;2-N"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001318"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38663.459039.7C"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21604"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39363.471806.BE"},{"key":"e_1_2_6_8_2","series-title":"IARC monographs on the evaluation of carcinogenic risks to humans","first-page":"477","volume-title":"Human Papillomaviruses","author":"International Agency for Research on Cancer","year":"2007"},{"key":"e_1_2_6_9_2","series-title":"IARC handbook of cancer prevention","first-page":"311","volume-title":"Cervical Cancer","author":"International Agency for Research on Cancer","year":"2005"},{"key":"e_1_2_6_10_2","series-title":"Socioeconomic differences in cancer incidence and mortality","first-page":"65","author":"Faggiano F","year":"1997"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000003811.98261.3e"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2006.049940"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200007000-00016"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20513"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.12.028"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60946-5"},{"volume-title":"Sosioekonomisen aseman luokitus 1989","year":"1989","key":"e_1_2_6_17_2"},{"key":"e_1_2_6_18_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life\u2010tables","volume":"34","author":"Cox DR","year":"1972","journal-title":"J R Stat Soc"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/69.1.239"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841869409098430"},{"key":"e_1_2_6_21_2","first-page":"1","article-title":"Finnish health and social welfare registers in epidemiological research","volume":"14","author":"Gissler M","year":"2004","journal-title":"Nor Epidemiol"},{"key":"e_1_2_6_22_2","unstructured":"Finnish Cancer Registry\u2014Institute for Statistical and Epidemiological Cancer Research: Cancer in Finland 2004 and 2005. Cancer Statistics of the National Research and Development Centre for Welfare and Health. Cancer Society of Finland Publication No. 72. Helsinki 2007."},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyn033"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn354"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.1999.1100"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5396.1460"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6051.1525"},{"key":"e_1_2_6_28_2","unstructured":"US Department of Health and Human Services.Reducing the health consequences of smoking: 25 years of progress. A report of the surgeon general. US Department of Health and Human Services Public Health Service Centers for Disease Control Center for Chronic Disease Prevention and Health Promotion Office on Smoking and Health 1989. DHHS Publication (CDC)89\u20138411."},{"key":"e_1_2_6_29_2","unstructured":"US Department of Health and Human Services.The Health Benefits of Smoking Cessation. A Report of the Surgeon General. USDHHS Centers for Disease Control. Office of Smoking and Health 1990. DHHS Publication (CDC)90\u20138416."},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6676.789"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.12.885"},{"key":"e_1_2_6_32_2","first-page":"2799","article-title":"The association of human papillomavirus 16\/18 infection with lung cancer among nonsmoking Taiwanese women","volume":"61","author":"Cheng Y","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.14.1763"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061741"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.24713","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.24713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T20:50:01Z","timestamp":1739220601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.24713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,13]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1002\/ijc.24713"],"URL":"https:\/\/doi.org\/10.1002\/ijc.24713","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"type":"print","value":"0020-7136"},{"type":"electronic","value":"1097-0215"}],"subject":[],"published":{"date-parts":[[2009,8,13]]}}}