{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:05:04Z","timestamp":1779721504817,"version":"3.53.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,7,8]],"date-time":"2009-07-08T00:00:00Z","timestamp":1247011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T00:00:00Z","timestamp":1251849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2010,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate gastric carcinoma\u2010associated antigen, MG7\u2010Ag, for detection of gastric cancer in a high\u2010risk population, a population\u2010based screening of gastric cancer was conducted in Linqu County, Shandong Province, China. In 2002 and 2003, a total of 2,710 participants aged 35\u201365 years received an endoscopic examination with 5 biopsies taken from standard sites with pathological diagnosis, and serum samples were collected to detect MG7\u2010Ag by serum\u2010based Immunopolymerase chain reaction (PCR) assay. The sensitivity and specificity of MG7\u2010Ag Immuno\u2010PCR assay in detecting of gastric cancer were assessed. Of 2,710 participants, 148 (5.46%) were determined to be MG7\u2010Ag positive. The sensitivity of MG7\u2010Ag Immuno\u2010PCR assay for the detection of gastric cancer was 77.5% (31 of 40 gastric cancer cases), the specificity was 95.62% (2,553 of 2,670 nongastric cancer subjects) and the accuracy was 73.12%. A total of 24 gastric cancer cases were in Stage I or II, of which 17 (70.8%) were MG7\u2010Ag positive. However, the proportion of MG7\u2010Ag positivity in subjects with superficial gastritis, chronic atrophic gastritis, intestinal metaplasia, indefinite dysplasia or dysplasia was ranged from 3.00% to 5.61% in comparison with 77.5% in those with gastric cancer. Our findings suggest that MG7\u2010Ag was a sensitive and specific serum biomarker and may have a potential for gastric cancer screening in the high\u2010risk population.<\/jats:p>","DOI":"10.1002\/ijc.24739","type":"journal-article","created":{"date-parts":[[2009,7,9]],"date-time":"2009-07-09T21:29:31Z","timestamp":1247174971000},"page":"469-473","source":"Crossref","is-referenced-by-count":33,"title":["Detection of gastric carcinoma\u2010associated MG7\u2010Ag by serum immuno\u2010PCR assay in a high\u2010risk Chinese population, with implication for 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