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The genes codifying these molecules are polymorphic and certain alleles have been associated with susceptibility to disease. Gastric cancer is associated with an\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    \u2010induced chronic inflammatory response. The aim of this work was to analyze whether polymorphisms in inflammation\u2010related genes are associated with the development of gastric cancer. We studied 447 Mexican adult patients including 228 with non\u2010atrophic gastritis, 98 with intestinal metaplasia, 63 with gastric cancer and 58 with duodenal ulcer, and 132 asymptomatic individuals as well. DNA from peripheral white blood cells was typed for the Single Nucleotide Polymorphisms (SNPs) \u2212308 of\n                    <jats:italic>TNF\u2010\u03b1<\/jats:italic>\n                    , +252 of\n                    <jats:italic>TNF\u2010\u03b2<\/jats:italic>\n                    , +190 of\n                    <jats:italic>HSP70\u20101<\/jats:italic>\n                    , +1267 of\n                    <jats:italic>HSP70\u20102<\/jats:italic>\n                    and +2437 of\n                    <jats:italic>HSP70\u2010HOM<\/jats:italic>\n                    . Compared with the asymptomatic group, we found a significant association of\n                    <jats:italic>TNF\u2010\u03b2*A<\/jats:italic>\n                    and\n                    <jats:italic>HSP70\u20101*C<\/jats:italic>\n                    alleles with gastric cancer (OR 5.69 and 3.76, respectively) and\n                    <jats:italic>HSP70\u20101*C<\/jats:italic>\n                    with duodenal ulcer (OR 3.08). Genotype\n                    <jats:italic>TNF\u2010\u03b2 G\/G<\/jats:italic>\n                    showed a significant gene\u2010dose effect with gastric cancer (OR 0.09); whereas\n                    <jats:italic>HSP70\u20101 C\/G<\/jats:italic>\n                    showed significant association with both, gastric cancer (OR 13.31) and duodenal ulcer (OR 16.19). Polymorphisms in\n                    <jats:italic>TNF<\/jats:italic>\n                    and\n                    <jats:italic>HSP70<\/jats:italic>\n                    showed a significant severity\u2010dose\u2010response as risk markers from preneoplastic lesions to gastric cancer in Mexican population, probably because of their association with an intense and sustained inflammatory response.\n                  <\/jats:p>","DOI":"10.1002\/ijc.24773","type":"journal-article","created":{"date-parts":[[2009,7,22]],"date-time":"2009-07-22T11:35:55Z","timestamp":1248262555000},"page":"1861-1868","source":"Crossref","is-referenced-by-count":46,"title":["Polymorphisms in\n                    <i>TNF<\/i>\n                    and\n                    <i>HSP\u201070<\/i>\n                    show a significant association with gastric cancer and duodenal 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