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Interestingly, an increase in expression of claudin\u20101 considerably reduced apoptosis rather than enhancing cell proliferation. However, claudin\u20101 expression and activity were unaffected by external stimuli or Akt and NF\u2010\u03baB activation. Notably, predominant cytoplasmic and nuclear localization of claudin\u20101 in NPC cells reflected the aforementioned feature. On the other hand, loss of epithelial morphology and E\u2010cadherin expression was associated with serum withdrawal in NPC cells. Interestingly, restoration of E\u2010cadherin inhibited the protein elevation and antiapoptotic activity of claudin\u20101. In conclusion, our data demonstrate the regulation and novel biological function of claudin\u20101 and indicate the important role of claudin\u20101 in NPC tumorigenesis.<\/jats:p>","DOI":"10.1002\/ijc.24857","type":"journal-article","created":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T19:17:44Z","timestamp":1252437464000},"page":"1353-1366","source":"Crossref","is-referenced-by-count":37,"title":["Upregulated claudin\u20101 expression confers resistance to cell death of nasopharyngeal carcinoma 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