{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:18:28Z","timestamp":1761488308286},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T00:00:00Z","timestamp":1252368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied the effectiveness of high\u2010risk human papillomavirus (hrHPV) triage for immediate colposcopy in women with borderline or mild dyskaryosis (BMD). In the Utrecht province of the Netherlands, women aged 30\u201360 years who participated in the regular cervical screening programme were offered hrHPV testing and cytology (intervention group) or cytology only (control group). In the intervention group (<jats:italic>n<\/jats:italic> = 337), women with BMD were immediately referred for colposcopy only if the sample was hrHPV positive. Women with a hrHPV negative test were advised to repeat cytology at 6 and 18 months and were referred for colposcopy if and when the repeat test result was positive (BMD or worse). In the control group (<jats:italic>n<\/jats:italic> = 329), referral of women with BMD was delayed until cytology was repeatedly positive at 6 or 18 months. The CIN3 detection rates were 10.7% (36\/337) in the intervention group and 6.4% (21\/329) in the control group (<jats:italic>p<\/jats:italic> = 0.047). Moreover, hrHPV triaging resulted in shorter time to diagnosis (154 <jats:italic>vs.<\/jats:italic> 381 days). Although the number of colposcopy referrals was 51.5% higher in the intervention group than in the control group, the medical costs per detected CIN3 were slightly lower ([euro] 4781 <jats:italic>vs.<\/jats:italic> [euro] 6235). If, in addition, hrHPV negative women had been referred back to routine screening at baseline, the CIN3 rate would have been 10.1% (34\/337) and colposcopy rate would only have been 30.4% higher than in the control group. This study shows that hrHPV triaging of women with BMD is at least as effective for detecting CIN3 as repeat cytology, also when hrHPV negative women are referred back to routine screening.<\/jats:p>","DOI":"10.1002\/ijc.24891","type":"journal-article","created":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T19:18:28Z","timestamp":1252437508000},"page":"2175-2181","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of HPV and cytology triage algorithms for women with borderline or mild dyskaryosis in population\u2010based cervical screening (VUSA\u2010screen study)"],"prefix":"10.1002","volume":"126","author":[{"given":"Dorien C.","family":"Rijkaart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Berkhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folkert J.","family":"van Kemenade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Rozendaal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 H.M.","family":"Verheijen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia","family":"Bulk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam E.","family":"Herreilers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim M.","family":"Verweij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.F.","family":"Snijders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris J.L.M.","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,12,29]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14955-0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.981"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1845"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.5858\/2003-127-1169-AHPTIT","article-title":"Adjunctive human papillomavirus testing in the 2\u2010year follow\u2010up of women with low\u2010grade cervical cytologic abnormalities: a randomized trial and economic evaluation","volume":"127","author":"Lytwyn A","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1322-7696(08)60559-4"},{"key":"e_1_2_6_7_2","first-page":"849","article-title":"Management of the low\u2010grade abnormal Pap smear: what are women's preferences?","volume":"51","author":"Melnikow J","year":"2002","journal-title":"J Fam Pract"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh037"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.5858\/2003-127-1169-AHPTIT","article-title":"Adjunctive human papillomavirus testing in the 2\u2010year follow\u2010up of women with low\u2010grade cervical cytologic abnormalities: a randomized trial and economic evaluation","volume":"127","author":"Lytwyn A","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21513"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38701.440961.7C"},{"key":"e_1_2_6_12_2","first-page":"1283","article-title":"[New version of the pathology practice guideline for cervical cytology: sharpened criteria for adequacy; expanded use of new techniques]","volume":"151","author":"van Kemenade FJ","year":"2007","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326965"},{"key":"e_1_2_6_14_2","unstructured":"National Health Service Screening Programme. (NHSCSP publication 1. Sheffield: NHS Cancer Screening Programmes; 2000) 1\u201036.2009."},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.011841"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02078-05"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb13299.x"},{"key":"e_1_2_6_18_2","first-page":"292","volume-title":"Obstetrical and gynaecological pathology","author":"Anderson MC","year":"1995"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1006\/gyno.1995.1212","article-title":"Observer agreement on interpreting colposcopic images of CIN","author":"Hopman EH","year":"1995","journal-title":"Gynecol Oncol"},{"key":"e_1_2_6_20_2","volume-title":"De effecten en kosten van het bevolkingsonderzoek naar baarmoederhalskanker in Nederland na de herstructurering","author":"van Ballegooijen M","year":"2006"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(92)90072-A"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh104"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.18.2372"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.049"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(02)00194-6"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000263461.71732.40"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22838"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.24891","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.24891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:22:07Z","timestamp":1697458927000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.24891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,29]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1002\/ijc.24891"],"URL":"https:\/\/doi.org\/10.1002\/ijc.24891","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,29]]}}}