{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:04:29Z","timestamp":1791338669065,"version":"4.3.1"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,10,6]],"date-time":"2009-10-06T00:00:00Z","timestamp":1254787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Burkitt lymphoma (BL) is a unique B\u2010cell non\u2010Hodgkin lymphoma with 3 established clinical\u2010epidemiological variants: endemic, sporadic and AIDS\u2010related BL. BL variants show characteristic dysregulation of\n                    <jats:italic>MYC<\/jats:italic>\n                    gene, but the causes of\n                    <jats:italic>MYC<\/jats:italic>\n                    dysregulation or BL arising at different ages are poorly understood. Therefore, we examined population\u2010based BL incidence patterns in the United States to determine age\u2010related risk. BL case and population data were obtained from the NCI's Surveillance, Epidemiology and End Results Databases (1973\u20132005). Standard cross\u2010sectional age\u2010standardized and age\u2010specific incidence rates were stratified by sex and race and supplemented with age\u2013period\u2013cohort models. We analyzed 3,058 BL cases diagnosed during 1,160,300,297 person\u2010years of observation. Age\u2010standardized incidence rates rose 6.8% per year (95% CI 4.5\u20139.1) for males and 7.1% (95% CI 3.2\u201311.1) for females during the study period. The rate among males was 3.2 times that among females, and among Whites 1.3 times that among Blacks. Male\u2010to\u2010female incidence rate ratios did not differ by race, but were 4.2 for pediatric (0\u201319 years), 4.1 for adult (20\u201359 years) and 2.0 for geriatric (\u226560 years) BL. Cross\u2010sectional age\u2010specific rates showed 2 separate peaks among males and females, near ages 10 and 75 years, and a 3rd peak near age 40 years among males. The tri\/bimodal incidence pattern was present in sensitivity analyses excluding registries with many HIV\/AIDS cases and in period\u2010specific, cohort\u2010specific analyses. To our knowledge, tri\/bimodal incidence patterns have not previously been reported for BL. Trimodal\/bimodal BL suggests heterogeneity in etiology or biology of BL diagnosed at different ages in males and females. \u00a9 2009 UICC.\n                  <\/jats:p>","DOI":"10.1002\/ijc.24934","type":"journal-article","created":{"date-parts":[[2009,10,6]],"date-time":"2009-10-06T15:27:56Z","timestamp":1254842876000},"page":"1732-1739","source":"Crossref","is-referenced-by-count":65,"title":["Trimodal age\u2010specific incidence patterns for Burkitt lymphoma in the United States, 1973\u20132005"],"prefix":"10.1002","volume":"126","author":[{"given":"Sam M.","family":"Mbulaiteye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishor","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha S.","family":"Linet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan S.","family":"Devesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004619704"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1963.7"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198109243051305"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-70-4-817"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.2.758"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.3.1124"},{"issue":"1","key":"e_1_2_6_8_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/annonc\/11.suppl_1.S3","article-title":"Lymphoma classification\u2013from controversy to consensus: the R.E.A.L. and WHO classification of lymphoid neoplasms","volume":"11","author":"Harris NL","year":"2000","journal-title":"Ann Oncol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055351"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/237033a0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2410"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2015"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(72)90025-4"},{"key":"e_1_2_6_14_2","unstructured":"SEER\u20109. 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