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It has been demonstrated that ICAM\u20101 expression increases with senescence in some cell types, however, the significance of this phenomenon in the context of malignant dissemination remains elusive. In this report we show that the adherence of SW480 and PSN\u20101 cells to senescent human omentum\u2010derived mesothelial cells (HOMCs) <jats:italic>in vitro<\/jats:italic> is greater than to early\u2010passage cells and that the effect is mediated by ICAM\u20101. Senescent HOMCs display increased expression of ICAM\u20101 mRNA and cell surface protein. The development of this phenotype is related to increased oxidative stress in senescent cells. The augmented ICAM\u20101 expression in HOMCs can be reduced by culturing cells with antioxidants; in contrast, exposure of HOMCs to an oxidant, t\u2010BHP, leads to cellular senescence and increased ICAM\u20101 expression. The effect is partly mediated by activation of p38 MAPK and AP\u20101 signaling pathways. Finally, culture of HOMCs in the presence of a strong antioxidant, PBN, significantly reduces the senescence\u2010associated increase in SW480 and PSN\u20101 cancer cell binding. These results indicate that increased oxidative stress and increased expression of ICAM\u20101 in senescent HOMCs may facilitate peritoneal adhesion of selected colorectal and pancreatic cancers.<\/jats:p>","DOI":"10.1002\/ijc.25036","type":"journal-article","created":{"date-parts":[[2009,11,10]],"date-time":"2009-11-10T17:26:07Z","timestamp":1257873967000},"page":"293-303","source":"Crossref","is-referenced-by-count":53,"title":["Oxidative stress\u2010dependent increase in ICAM\u20101 expression promotes adhesion of colorectal and pancreatic cancers to the senescent peritoneal 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