{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T23:56:32Z","timestamp":1776642992694,"version":"3.51.2"},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,12,3]],"date-time":"2009-12-03T00:00:00Z","timestamp":1259798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidemiological studies have evaluated whether the impact of alcohol intake on breast cancer risk is modified by use of exogenous estrogens, folate intake, body weight and smoking status, but results have been inconsistent. Further, effect modification by intake of isoflavones and alcohol\u2010induced facial flushing, which are prevalent in Asian populations, have not been investigated. We investigated the association between alcohol intake and breast cancer risk and whether the association is modified by these factors among 50,757 premenopausal and postmenopausal women (aged 40\u201369 years) in the population\u2010based Japan Public Health Center\u2010based Prospective Study. Alcohol consumption and other related factors were assessed using self\u2010reported questionnaires. Through to the end of 2006, 572 patients were identified. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated by hazard ratios derived from Cox proportional hazards regression models. Compared with never\u2010drinkers, regular alcohol drinkers (&gt;150 g of ethanol\/week) had a higher risk of the development of breast cancer; the multivariable\u2010adjusted RRs were 1.75 (95% CI = 1.16\u20132.65; <jats:italic>p<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.035) for overall, 1.78 (95% CI = 1.09\u20132.90) for premenopausal and 1.21 (95% CI = 0.53\u20132.75) for postmenopausal women. There was no statistical evidence for effect modification by menopausal status, use of exogenous estrogens, intakes of isoflavone and folate, body weight, alcohol\u2010induced facial flushing or smoking (All <jats:italic>p<\/jats:italic><jats:sub>interactions<\/jats:sub> \u2265 0.15). Excessive alcohol intake was associated with an increase in the risk of breast cancer in this population. There was no statistical evidence for effect modification.<\/jats:p>","DOI":"10.1002\/ijc.25079","type":"journal-article","created":{"date-parts":[[2009,12,3]],"date-time":"2009-12-03T13:17:08Z","timestamp":1259846228000},"page":"685-695","source":"Crossref","is-referenced-by-count":38,"title":["Alcohol consumption\u2010associated breast cancer incidence and potential effect modifiers: the Japan Public Health Center\u2010based Prospective Study"],"prefix":"10.1002","volume":"127","author":[{"given":"Reiko","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manami","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuka","family":"Sasazuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norie","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiki","family":"Yamaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Shimazu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichiro","family":"Tsugane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,5,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70099-2"},{"key":"e_1_2_6_3_2","unstructured":"IARC. Preamble to the IARC monographs on the evaluation risks to humans. Available at:http:\/\/monographs.iarc.fr\/ENG\/Preamble\/CurrentPreamble.pdf ed. Accessed March 2 2007."},{"key":"e_1_2_6_4_2","volume-title":"Food, nutrition, physical activity, and the prevention of cancer: a global perspective ed","author":"Research WCRFAIfC","year":"2007"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600596"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23184"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn074"},{"key":"e_1_2_6_8_2","volume-title":"Current status of the nations health and nutrition in Japan, 2004 edn","author":"National Health and Nutrition Examination Survey","year":"2006"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2006.09.003"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.cej.0000228410.14095.2d"},{"key":"e_1_2_6_11_2","unstructured":"The Ministry of Health Law. Dynamic statistics of the population. Available at:http:\/\/www.mhlw.go.jp\/toukei\/saikin\/hw\/jinkou\/geppo\/nengai08\/index.html. Accessed August 8 2009."},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1995.tb03000.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hym062"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20980"},{"key":"e_1_2_6_15_2","first-page":"5635","article-title":"Alcohol stimulates estrogen receptor signaling in human breast cancer cell lines","volume":"60","author":"Fan S","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00419-0"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.9.722"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.9.710"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1987.48.295"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57602-X"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(91)90128-9"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(94)00165-2"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1997.tb04256.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2191"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2005.04.005"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009271"},{"key":"e_1_2_6_27_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1158\/1055-9965.41.14.1","article-title":"Differences in breast cancer risk factors by tumor marker subtypes among premenopausal Vietnamese and Chinese women","volume":"14","author":"Nichols HB","year":"2005","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38551.446470.06"},{"key":"e_1_2_6_29_2","first-page":"1104","article-title":"Interaction of dietary folate intake, alcohol, and risk of hormone receptor\u2010defined breast cancer in a prospective study of postmenopausal women","volume":"11","author":"Sellers TA","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0083"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-08-0692"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23195"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji341"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-10-200211190-00008"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(02)00777-5"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.175.4020.449"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00288263"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00208273"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70019-1"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200302000-00002"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.2188\/jea.11.6sup_24"},{"key":"e_1_2_6_42_2","first-page":"1492","article-title":"Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle\u2010aged and elderly Japanese men and women: Japan Public Health Center\u2010based prospective study","volume":"12","author":"Otani T","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602277"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.2188\/jea.13.1sup_125"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.2188\/jea.13.1sup_51"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.2188\/jea.13.1sup_134"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.2188\/jea.6.45"},{"key":"e_1_2_6_48_2","volume-title":"Standard tables of food composition in Japan","author":"The Council for Science and Technology, Ministry of Education C Sports SaT, Japan","year":"1982"},{"key":"e_1_2_6_49_2","volume-title":"Standard tables of food composition in Japan","author":"The Council for Science and Technology, Ministry of Education C Sports SaT, Japan","year":"2005"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195122978.001.0001"},{"key":"e_1_2_6_51_2","volume-title":"International classification of diseases for oncology","author":"World Health Organization","year":"2000"},{"key":"e_1_2_6_52_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009034"},{"key":"e_1_2_6_53_2","volume-title":"Modeling survival data in medical researched","author":"Collett D","year":"1999"},{"key":"e_1_2_6_54_2","volume-title":"Epidemiology: an introductioned","author":"Rothman KJ","year":"2002"},{"issue":"884","key":"e_1_2_6_55_2","first-page":"5","article-title":"Re: confidence limits made easy: interval estimation using a substitution method","volume":"149","author":"Greenland S","year":"1999","journal-title":"Am J Epidemiol"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_2_6_57_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.7.535"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn514"},{"key":"e_1_2_6_59_2","first-page":"603","article-title":"Ethanol stimulates the secretion of matrix metalloproteinases 2 and 9 in MCF\u20107 human breast cancer cells","volume":"15","author":"Etique N","year":"2006","journal-title":"Oncol Rep"},{"key":"e_1_2_6_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-006-0112-9"},{"key":"e_1_2_6_61_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.102913"},{"key":"e_1_2_6_62_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.17.1632"},{"key":"e_1_2_6_63_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200107000-00012"},{"key":"e_1_2_6_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602313"},{"key":"e_1_2_6_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk006"},{"key":"e_1_2_6_66_2","first-page":"161","article-title":"Alcohol, folate, methionine, and risk of incident breast cancer in the American Cancer Society Cancer Prevention Study II Nutrition Cohort","volume":"12","author":"Feigelson HS","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2005.06.048"},{"key":"e_1_2_6_68_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20709"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.25079","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.25079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:18:53Z","timestamp":1697433533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.25079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,24]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1002\/ijc.25079"],"URL":"https:\/\/doi.org\/10.1002\/ijc.25079","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,24]]}}}