{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:14:05Z","timestamp":1782515645254,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T00:00:00Z","timestamp":1260316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2010,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although cooking emission from high\u2010temperature frying has been deemed a Group 2A carcinogen by the International Agency for Research on Cancer, little is known about its impact on cervical tumorigenesis. To investigate the precancerous consequence of cooking oil fumes on cervical intraepithelial neoplasm (CIN), a community\u2010based case\u2010control study, which takes all known risk factors into consideration, was conducted in Taiwan. From 2003 to 2008, in a Pap smear screening and biopsy examination network, 206 pathology\u2010verified women with inflammations\/atypical squamous cells of undetermined significance or CIN grade\u20101 (CIN1) and 73 with CIN2\u22123 (defined as low\u2010grade squamous intraepithelial lesions (LGSIL) and high\u2010grade squamous intraepithelial lesions (HGSIL), respectively); and 1,200 area\u2010and\u2010age\u2010matched controls with negative cytology were recruited. Multinomial logistic regression was applied in the multivariate analysis to determine the likelihood of contracting LGSIL or HGSIL. The risks of the two lesions increased with the increase of carcinogenic high\u2010risk human papillomavirus DNA load, with a clear dose\u2010response relationship. Chefs were observed to experience a 7.9\u2010fold elevated HGSIL risk. Kitchens with poor fume ventilation during the main cooking life\u2010stage correlated to a 3.7\u2010fold risk of HGSIL, but not for LGSIL. More than 1 hr of daily cooking in kitchens with poor fume conditions appeared to confer an 8.4\u2010fold HGSIL risk, with an 8.3\u2010fold heterogeneously higher odds ratio than that (aOR = 1.0) for LGSIL. Similar risk pattern has been reproduced among never\u2010smoking women. Our findings demonstrate the association between indoor exposure to cooking fumes from heated oil and the late development of cervical precancerous lesions. This final conclusion needs to be verified by future research.<\/jats:p>","DOI":"10.1002\/ijc.25108","type":"journal-article","created":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T22:40:16Z","timestamp":1260398416000},"page":"932-941","source":"Crossref","is-referenced-by-count":40,"title":["The precancerous effect of emitted cooking oil fumes on precursor lesions of cervical cancer"],"prefix":"10.1002","volume":"127","author":[{"given":"Chien\u2010Hung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheau\u2010Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung\u2010Yu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruei\u2010Nian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chieh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te\u2010Fu","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eing\u2010Mei","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Chen","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joh\u2010Jong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Ting","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hsiu","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao\u2010Ling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Tsang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010181"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70969-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910400505"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116654"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/26.1.24"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011270521900"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2932"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn699"},{"key":"e_1_2_6_10_2","first-page":"1215","article-title":"Fumes from meat cooking and lung cancer risk in Chinese women","volume":"9","author":"Seow A","year":"2000","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1998.3876"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1997.3798"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(00)00463-8"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11222"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0399"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh115"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.18.1406"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.2.224"},{"key":"e_1_2_6_20_2","unstructured":"Department of Health Executive Yuan Republic of China (ROC). 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