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MicroRNA (miRNA), a novel class of RNA that regulates gene expression, is involved in many cellular processes such as growth, development and apoptosis. It has recently been linked to several cancer phenotypes. However, aberrant miRNA expression and its pathologic significance in ATL are not well documented. Here, we investigated the role of miRNAs in HTLV\u20101\u2010related leukemogenesis. The results showed that miR\u2010146a was upregulated in HTLV\u20101\u2010infected T\u2010cell lines compared to uninfected T\u2010cell lines. Tax\u2010induced miR\u2010146a expression in a NF\u2010\u03baB\u2010dependent manner and inhibited the expression of gene harboring the target sequence of miR\u2010146a on its 3\u2032UTR. Inhibition of miR\u2010146a function by anti\u2010miRNA inhibitor reduced the proliferation of HTLV\u20101\u2010infected T\u2010cell lines but not that of uninfected T\u2010cell lines. Moreover, overexpression of miR\u2010146a enhanced the growth of an HTLV\u20101\u2010infected T\u2010cell line. Our findings suggest that miR\u2010146a is a potentially suitable therapeutic target of ATL.<\/jats:p>","DOI":"10.1002\/ijc.25115","type":"journal-article","created":{"date-parts":[[2009,12,16]],"date-time":"2009-12-16T16:03:58Z","timestamp":1260979438000},"page":"2300-2309","source":"Crossref","is-referenced-by-count":51,"title":["MicroRNA miR\u2010146a is induced by HTLV\u20101 tax and increases the growth of HTLV\u20101\u2010infected T\u2010cells"],"prefix":"10.1002","volume":"130","author":[{"given":"Mariko","family":"Tomita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuetsu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2111"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1389"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.9.3351"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-1-20"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00431-7"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062961"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.927801"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.035"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1309\/2JK279BU2G743MWJ"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1840"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1997"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06487"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209915"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0769"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-5-100"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-189845"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.71.6.4445-4451.1997"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02136-07"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gni178"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_6_23_2","first-page":"2360","article-title":"Constitutive activation of NF\u2010\u03baB in primary adult T\u2010cell leukemia cells","volume":"93","author":"Mori N","year":"1999","journal-title":"Blood"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1990.tb02554.x"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208059"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605298103"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.4161\/rna.4.3.5206"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002557"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.874808"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802682105"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.171"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.25115","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.25115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T12:08:08Z","timestamp":1697458088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.25115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,16]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,5,15]]}},"alternative-id":["10.1002\/ijc.25115"],"URL":"https:\/\/doi.org\/10.1002\/ijc.25115","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,16]]}}}