{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:29:59Z","timestamp":1781195399557,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,12,28]],"date-time":"2009-12-28T00:00:00Z","timestamp":1261958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To determine why a vaginal self\u2010collection tested for high\u2010risk human papillomavirus (HR\u2010HPV) by Hybrid Capture 2\u00ae (hc2) has lower sensitivity and specificity for cervical intraepithelial neoplasia Grade 2 or worse (\u2265CIN 2), we collected 5 specimens (endocervix, upper and lower vagina, perineum, vaginal self\u2010collection) from 2,625 women. Endocervical and self\u2010collected specimens had HR\u2010HPV tests by hc2. All 5 anogenital specimens were tested for 37 HPV genotypes [Linear Array\u00ae, (LA)] from 397 women hc2 positive in endocervical or self\u2010collected specimens and for a randomly selected 71 of 2,228 women hc2 negative on both specimens. Three hundred nintey\u2010five women who screened positive by hc2 or had abnormal cytology underwent colposcopic evaluation. Of 47 women with \u2265CIN 2, hc2 was positive in 97.9% (46\/47) of endocervical and 80.9% (38\/47), <jats:italic>p<\/jats:italic> = 0.008 of self\u2010collected specimens. Seven of 9 women with \u2265CIN 2 and negative self\u2010collected hc2 tests were positive for HR\u2010HPV by LA. Of 2,578 women without \u2265CIN 2, hc2 was positive in 9.8% (253\/2,578) of endocervical and 11.4% (294\/2,578), <jats:italic>p<\/jats:italic> = 0.001 of self\u2010collected specimens. Of the 41 more women without \u2265CIN 2 that tested hc2 positive on the self\u2010collected but negative on endocervical specimen, LA tested positive for HR\u2010HPV in 24, negative for HPV in 11 and negative for HR\u2010HPV but positive for low\u2010risk HPV in 6. Lower sensitivity of self\u2010collected specimens is secondary to lower levels of vaginal HR\u2010HPV. The principal cause of the lower specificity of self\u2010collected specimens is HR\u2010HPV present solely in the vagina, which is not associated with \u2265CIN 2.<\/jats:p>","DOI":"10.1002\/ijc.25144","type":"journal-article","created":{"date-parts":[[2009,12,28]],"date-time":"2009-12-28T15:11:32Z","timestamp":1262013092000},"page":"1151-1157","source":"Crossref","is-referenced-by-count":77,"title":["Prevalence of type\u2010specific human papillomavirus in endocervical, upper and lower vaginal, perineal and vaginal self\u2010collected specimens: Implications for vaginal self\u2010collection"],"prefix":"10.1002","volume":"127","author":[{"given":"Jerome L.","family":"Belinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayineur","family":"Niyazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Pretorius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Taddeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul J.","family":"Burchette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Lin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016340500432457"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2005.00713.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00490-3"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/IGC.0b013e318197f479"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00128360-200304000-00007"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2001.6370"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2003.13611.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)40621-6"},{"key":"e_1_2_5_10_2","volume-title":"Hybrid Capture 2\u00ae Package Insert","author":"Qiagen, Corp.","year":"2005"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00824-08"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/421916"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji187"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.02.001"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.10.3020-3027.1998"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf180"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(03)00418-6"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22991"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.25144","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.25144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T17:47:52Z","timestamp":1697478472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.25144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,25]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1002\/ijc.25144"],"URL":"https:\/\/doi.org\/10.1002\/ijc.25144","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,25]]}}}