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Results from previous studies suggest a family history of select cancers (<jats:italic>i.e<\/jats:italic>., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case\u2010control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case\u2010control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate\u2010adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19\u20132.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12\u20131.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52\u20131.31), breast cancer (OR = 1.21, 95% CI = 0.97\u20131.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93\u20131.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.<\/jats:p>","DOI":"10.1002\/ijc.25148","type":"journal-article","created":{"date-parts":[[2010,1,4]],"date-time":"2010-01-04T16:42:44Z","timestamp":1262623364000},"page":"1421-1428","source":"Crossref","is-referenced-by-count":125,"title":["Family history of cancer and risk of pancreatic cancer: A pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan)"],"prefix":"10.1002","volume":"127","author":[{"given":"Eric J.","family":"Jacobs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Chanock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S.","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"LaCroix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"McWilliams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Steplowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael Z.","family":"Stolzenberg\u2010Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan A.","family":"Arslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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