{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:13:44Z","timestamp":1790000024307,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T00:00:00Z","timestamp":1265587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2010,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Equatorial Africa has among the highest incidences of Kaposi's sarcoma (KS) in the world, thus earning the name \u201cKS Belt.\u201d This was the case even before the HIV epidemic. To date, there is no clear evidence that HHV\u20108 seroprevalence is higher in this region but interpretation of the available literature is tempered by differences in serologic assays used across studies. We examined representatively sampled ambulatory adults in Uganda, which is in the \u201cKS Belt,\u201d and in Zimbabwe and South Africa which are outside the Belt, for HHV\u20108 antibodies. All serologic assays were uniformly performed in the same reference laboratory by the same personnel. In the base\u2010case serologic algorithm, seropositivity was defined by reactivity in an immunofluorescence assay or in 2 enzyme immunoassays. A total of 2,375 participants were examined. In Uganda, HHV\u20108 seroprevalence was high early in adulthood (35.5% by age 21) without significant change thereafter. In contrast, HHV\u20108 seroprevalence early in adulthood was lower in Zimbabwe and South Africa (13.7 and 10.8%, respectively) but increased with age. After age adjustment, Ugandans had 3.24\u2010fold greater odds of being HHV\u20108 infected than South Africans (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) and 2.22\u2010fold greater odds than Zimbabweans (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). Inferences were unchanged using all other serologic algorithms evaluated. In conclusion, HHV\u20108 infection is substantially more common in Uganda than in Zimbabwe and South Africa. These findings help to explain the high KS incidence in the \u201cKS Belt\u201d and underscore the importance of a uniform approach to HHV\u20108 antibody testing.\n                  <\/jats:p>","DOI":"10.1002\/ijc.25235","type":"journal-article","created":{"date-parts":[[2010,2,8]],"date-time":"2010-02-08T13:29:57Z","timestamp":1265635797000},"page":"2395-2401","source":"Crossref","is-referenced-by-count":96,"title":["Substantial regional differences in human herpesvirus 8 seroprevalence in sub\u2010Saharan Africa: Insights on the origin of the \u201cKaposi's sarcoma belt\u201d"],"prefix":"10.1002","volume":"127","author":[{"given":"Sheila C.","family":"Dollard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M. Graves","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Mermin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midion","family":"Chidzonga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsungai","family":"Chipato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline H.","family":"Shiboski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Brander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anisa","family":"Mosam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Photini","family":"Kiepiela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Hladik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey N.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,8]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.717"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92252-O"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91619-9"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607253350403"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804023381403"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199818000-00018"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/315039"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804023381403"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0896-918"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/518791"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010195"},{"key":"e_1_2_5_14_2","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1128\/JCM.36.6.1784-1786.1998","article-title":"High human herpesvirus 8 seroprevalence in the homosexual population in Switzerland","volume":"36","author":"Regamey N","year":"1998","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980812)77:4<543::AID-IJC12>3.0.CO;2-7"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90001-L"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2005.01491.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.3.439-464.2002"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600745"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200012)62:4<498::AID-JMV15>3.0.CO;2-B"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055009"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.6.1574-1577.1998"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.6.2174-2180.2000"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2005.04334.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00490.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1086\/598859"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1086\/423326"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.1.31-a"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10817"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/374973"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200212060-00014"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20001215)88:6<1003::AID-IJC26>3.0.CO;2-9"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1086\/600103"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200210180-00013"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199814000-00024"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02523.x"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31802f12ea"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn125"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1086\/367985"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200306010-00015"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(99)00061-X"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199909000-00010"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20242"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1086\/367703"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.25235","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.25235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T02:06:37Z","timestamp":1697421997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.25235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,8]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,11,15]]}},"alternative-id":["10.1002\/ijc.25235"],"URL":"https:\/\/doi.org\/10.1002\/ijc.25235","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.7783956.8120054","asserted-by":"object"}]},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,8]]}}}