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The aim of the study was to identify predictors of GC occurrence among patients with gastric preneoplastic lesions. A prospective and retrospective follow\u2010up study was carried out in a province in Spain with one of the highest risk of GC. The study included 478 patients who underwent gastric biopsy in 1988\u20131994 with diagnoses of normal mucosa, nonatrophic gastritis (NAG), non\u2010metaplastic multifocal atrophic gastritis (MAG) and complete or incomplete intestinal metaplasia (IM) and who accepted to undergo a new biopsy during 2005\u20132007 or had an event during follow up. Inter\u2010 and intra\u2010observer variability of histological diagnosis was assessed. Analysis was done using Cox proportional hazards risk (HR) models. The mean age of the patients was 50 years, 47% were males and the mean follow\u2010up time was 12.8 years. During follow\u2010up, 23 GC (4.8%) were diagnosed (21 adenocarcinomas and 2 lymphomas) with an incidence of 3.77 per 1,000 person per year. The incidence rate of GC for those with incomplete IM was 16.5 per 1,000 person years. Out the 21 adenocarcinomas, 16 had an incomplete IM in the baseline diagnosis. Incomplete IM (HR 11.3; 95% CI 3.8\u201333.9) and a family history of GC (HR 6.1; 95% CI 1.7\u201322.4) were the strongest risk factors for gastric adenocarcinoma. Subtyping of IM and family history of GC may be useful for the identification of high\u2010risk patients who need more intensive surveillance.<\/jats:p>","DOI":"10.1002\/ijc.25273","type":"journal-article","created":{"date-parts":[[2010,2,22]],"date-time":"2010-02-22T12:07:12Z","timestamp":1266840432000},"page":"2654-2660","source":"Crossref","is-referenced-by-count":75,"title":["Gastric cancer occurrence in preneoplastic lesions: A long\u2010term follow\u2010up in a high\u2010risk area in Spain"],"prefix":"10.1002","volume":"127","author":[{"given":"Carlos A.","family":"Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Maria","family":"Ruiz Liso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Bonet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul M.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Sala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Capella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Sanz\u2010Anquela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,22]]},"reference":[{"issue":"1","key":"e_1_2_6_2_2","first-page":"S37","article-title":"Helicobacter pylori and gastric carcinogenesis","volume":"19","author":"Correa P","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90498-5"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05774.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00475.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2006.03.015"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg754"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19991126)83:5<615::AID-IJC8>3.0.CO;2-L"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.071"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910570306"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i36.5757"},{"key":"e_1_2_6_13_2","unstructured":"Instituto de Salud Carlos III Centro Nacional de Epidemiolog\u00eda. 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