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In this study, we analyzed 42 genetic variations among 15 candidate genes in 307 AML patients and 560 age\u2010sex matched controls. Their associations with chemotherapy response were further evaluated in combination with other well\u2010established prognostic factors. An increased risk of AML was found in individuals heterozygous for <jats:italic>XPD<\/jats:italic> 2251A&gt;C (rs13181) with an odds ratio (OR) of 1.637 (95% confidence interval [CI]: 1.118\u20132.395), and the increased risk could be attributed to C allele (OR = 1.505, 95% CI: 1.061\u20132.134). Postchemotherapy response analysis revealed that AML patients heterozygous for <jats:italic>ATM<\/jats:italic> 4138C&gt;T (rs3092856) or GG homozygous for <jats:italic>TP53<\/jats:italic> 215C&gt;G (rs1042522) were independently linked to inferior treatment outcomes. These results uncover novel prognostic factors for AML patients treated with chemotherapy and may also indicate an etiological role of <jats:italic>XPD<\/jats:italic> in this disease.<\/jats:p>","DOI":"10.1002\/ijc.25318","type":"journal-article","created":{"date-parts":[[2010,3,15]],"date-time":"2010-03-15T15:25:10Z","timestamp":1268666710000},"page":"233-238","source":"Crossref","is-referenced-by-count":41,"title":["Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid 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