{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:17:36Z","timestamp":1790792256884,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T00:00:00Z","timestamp":1290470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2011,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Subungual exostosis is a benign bone\u2010 and cartilage\u2010forming tumor known to harbor a pathognomonic t(X;6)(q22;q13\u201014). Using global gene expression analysis and quantitative real\u2010time PCR, we could show that this translocation results in increased expression of the\n                    <jats:italic>IRS4<\/jats:italic>\n                    gene, presumably due to disruption and\/or exchange of regulatory sequences with the translocation partner, the\n                    <jats:italic>COL12A1<\/jats:italic>\n                    gene. A corresponding deregulation at the protein level could be demonstrated in primary cell cultures using a combination of fluorescence\n                    <jats:italic>in situ<\/jats:italic>\n                    hybridization and immunostaining. As the t(X;6) usually is the sole cytogenetic aberration in subungual exostosis, the deregulated expression of\n                    <jats:italic>IRS4<\/jats:italic>\n                    is likely to be pathogenetically essential. The exact role of IRS4 is still poorly investigated, but IRS proteins are known to act as mediators of signaling from receptors, such as the insulin and insulin\u2010like growth factor 1 receptors, and thus have an important effect on cell growth and survival.\n                  <\/jats:p>","DOI":"10.1002\/ijc.25353","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T11:22:36Z","timestamp":1269516156000},"page":"487-491","source":"Crossref","is-referenced-by-count":38,"title":["The t(X;6) in subungual exostosis results in transcriptional deregulation of the gene for insulin receptor substrate 4"],"prefix":"10.1002","volume":"128","author":[{"given":"Fredrik","family":"Mertens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emely","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Mandahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Picci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio R.","family":"Perez\u2010Atayde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignace","family":"Samson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raf","family":"Sciot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Debiec\u2010Rychter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2091"},{"key":"e_1_2_6_3_2","volume-title":"Mitelman database of chromosome aberrations in cancer","author":"Mitelman F","year":"2009"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199902)24:2<162::AID-GCC11>3.0.CO;2-7"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126642.61690.d6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21586"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198805000-00005"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1996.tb01205.x"},{"key":"e_1_2_6_9_2","volume-title":"World Health Organization classification of tumours. 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