{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T07:10:46Z","timestamp":1723273846483},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,11,27]],"date-time":"2010-11-27T00:00:00Z","timestamp":1290816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously reported decreased lymphocyte proliferative responses among older women with persistent human papillomavirus (HPV) infection. To characterize the phenotype of peripheral lymphocytes associated with persistent HPV infection, we evaluated the expression of different cell surface markers in peripheral blood mononuclear cells (PBMCs) from a case\u2013control study within a 10,049 woman population\u2010based cohort study in Guanacaste, Costa Rica. Women in the cohort aged 46\u201374 and with HPV results at their 5th year anniversary visit were considered, and all women (<jats:italic>n<\/jats:italic> = 87) with persistent HPV infections, all women (<jats:italic>n<\/jats:italic> = 196) with transient HPV infections and a random sample of HPV DNA\u2010negative women (<jats:italic>n<\/jats:italic> = 261) frequency\u2010matched to cases on age were selected for this study. A median of 3 years after the case\u2013control matching visit, cervical cells were collected for liquid\u2010based cytology and repeat HPV DNA genotyping. Blood was obtained from which PBMCs were extracted and cryopreserved for immunological phenotyping <jats:italic>via<\/jats:italic> flow cytometry. Significant increases in risk of HPV persistence were observed for 3 marker subsets indicative of immune cell activation\/differentiation. Relative risk estimates were 5.4 (95% CI = 2.2\u201313.3) for CD69<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>, 2.6 (95% CI = 1.2\u20135.9) for HLADR<jats:sup>+<\/jats:sup>CD3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup> and 2.3 (95% CI = 1.1\u20134.7) for CD45RO<jats:sup>+<\/jats:sup>CD27<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>+<\/jats:sup>. A significant decrease in HPV persistence was observed for a subset marker indicative of an immature, undifferentiated memory state CD45RO<jats:sup>+<\/jats:sup>CD27<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup> (OR = 0.36; 95% CI = 0.17\u20130.76). Adjustment for these markers only partially explained the previously reported association between decreased lymphoproliferative responses and persistent HPV infection. Whether phenotypic alterations observed predispose to HPV persistence or result from it should be the focus of future studies.<\/jats:p>","DOI":"10.1002\/ijc.25371","type":"journal-article","created":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T13:20:38Z","timestamp":1270646438000},"page":"597-607","source":"Crossref","is-referenced-by-count":6,"title":["Alterations of T\u2010cell surface markers in older women with persistent human papillomavirus infection"],"prefix":"10.1002","volume":"128","author":[{"given":"Ana Cecilia","family":"Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso 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