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Lately, the family of platelet\u2010derived growth factors (PDGFs) has shifted to the center of interest. We have reported on spontaneously developing liver fibrosis in PDGF\u2010B transgenic mice. Since HCC rarely occurs in healthy liver, but dramatically increases at the cirrhosis stage of which liver fibrosis is a preliminary stage, we investigated liver cancer development in chemically induced liver carcinogenesis in these mice. HCC induction was performed by treatment of the mice with diethylnitrosamine and phenobarbital. At an age of 6 months, the tumor development of these animals was analyzed. Not only the development of dysplastic lesions in PDGF\u2010B transgenic mice was significantly increased but also their malignant transformation to HCC. Furthermore, we were able to establish a key role of PDGF\u2010B signaling at diverse stages of liver cancer development. Here, we show that development of liver fibrosis is likely through upregulation of TGF\u2010\u03b2 receptors by PDGF\u2010B. Additionally, overexpression of PDGF\u2010B also leads to an increased expression of \u03b2\u2010catenin as well as vascular endothelial growth factor and platelet endothelial cell adhesion molecule\u20101 (PECAM\u20101\/CD31), all factors with established roles in carcinogenesis. We were able to extend the understanding of key genetic regulators in HCC development by PDGF\u2010B and decode essential downstream signals.<\/jats:p>","DOI":"10.1002\/ijc.25469","type":"journal-article","created":{"date-parts":[[2010,5,23]],"date-time":"2010-05-23T09:17:10Z","timestamp":1274606230000},"page":"1259-1268","source":"Crossref","is-referenced-by-count":55,"title":["Liver specific overexpression of platelet\u2010derived growth factor\u2010B accelerates liver cancer development in chemically induced liver carcinogenesis"],"prefix":"10.1002","volume":"128","author":[{"given":"Thorsten","family":"Maass","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian 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