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As the factors promoting this process are poorly understood, we investigated the ovarian cancer\u2013peritoneal interaction by means of <jats:italic>in vitro<\/jats:italic> coculture experiments with ovarian cancer (OVCAR\u20105 and SKOV\u20103) and peritoneal (LP\u20109) cells. One of the proteins differentially expressed in the coculture secretome was identified by MALDI\u2010TOF\/TOF mass spectrometry as the extracellular matrix protein transforming growth factor\u2010beta\u2010induced protein (TGFBIp, also known as \u03b2ig\u2010H3). Immunohistochemistry showed high TGFBIp levels in normal surface ovarian epithelial and peritoneal cells, whereas TGFBIp levels in primary serous ovarian carcinomas and matching metastatic implants was very low. In functional <jats:italic>in vitro<\/jats:italic> experiments, treatment with recombinant TGFBIp significantly increased the motility and invasiveness of OVCAR\u20105 and SKOV\u20103 cells and significantly increased ovarian cancer cell (OVCAR\u20105, OVCAR\u20103 and SKOV\u20103) adhesion to LP\u20109 cells. TGFBIp was found to be processed at both the N\u2010 and C\u2010terminus in the secretome of the ovarian cancer\u2013peritoneal cell coculture. Plasmin inhibitors blocked TGFBIp processing and significantly reduced OVCAR\u20105 cell adhesion to peritoneal cells. We conclude that TGFBIp expressed by peritoneal cells increases the metastatic potential of ovarian cancer cells. TGFBIp is therefore a potential novel therapeutic target against ovarian cancer.<\/jats:p>","DOI":"10.1002\/ijc.25494","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T15:36:03Z","timestamp":1275492963000},"page":"1570-1584","source":"Crossref","is-referenced-by-count":70,"title":["Transforming growth factor\u2010beta\u2010induced protein secreted by peritoneal cells increases the metastatic potential of ovarian cancer cells"],"prefix":"10.1002","volume":"128","author":[{"given":"Miranda P.","family":"Ween","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor A.","family":"Lokman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond 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