{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:15:49Z","timestamp":1790158549394,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,6,7]],"date-time":"2010-06-07T00:00:00Z","timestamp":1275868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic lymphocytic leukemia (CLL) cells show constitutive nuclear factor kappa B (NF\u2010\u03baB) activation, which may have a pathogenetic role. The mechanisms causing this NF\u2010\u03baB activity are poorly understood. A20, encoded by the <jats:italic>TNFAIP3<\/jats:italic> gene, is a repressor of the NF\u2010\u03baB pathway and was recently shown to be frequently inactivated by deletions and\/or point mutations in several types of B\u2010cell lymphomas. Here, we studied 48 CLL, including at least 12 cases with a deletion of one allele of <jats:italic>TNFAIP3<\/jats:italic>, for mutations. However, only one case harboured a silent mutation, all other cases were unmutated. Therefore, A20 inactivation plays no significant role in the pathogenesis of CLL, and the recurrent deletion in CLL on 6q21\u201023, where <jats:italic>TNFAIP3<\/jats:italic> is located, likely affects other gene(s).<\/jats:p>","DOI":"10.1002\/ijc.25497","type":"journal-article","created":{"date-parts":[[2010,6,7]],"date-time":"2010-06-07T15:33:17Z","timestamp":1275924797000},"page":"1747-1750","source":"Crossref","is-referenced-by-count":18,"title":["Mutation analysis of the <i>TNFAIP3<\/i> (A20) tumor suppressor gene in CLL"],"prefix":"10.1002","volume":"128","author":[{"given":"Claudia","family":"Philipp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Edelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"B\u00fchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Stilgenbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"K\u00fcppers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,1,28]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2764"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.6.1840"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.6.1848"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403398"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-139725"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.2200"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-125278"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.234"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07968"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-194852"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07969"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-174110"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20090528"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2004.07.012"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401499"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0304717101"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.25497","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.25497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T20:20:49Z","timestamp":1697487649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.25497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,28]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1002\/ijc.25497"],"URL":"https:\/\/doi.org\/10.1002\/ijc.25497","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,28]]}}}