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Previously, we demonstrated that the expressions of orexigenic peptides increased and anorexigenic peptides decreased under cachectic conditions in rats carrying tumors secreting PTHrP. In this study, we investigated whether such changes in the expression of hypothalamic feeding\u2010regulating peptides can be solely attributed to PTHrP or are a general response under cachectic conditions. Cachectic syndromes were induced in rats by: (<jats:italic>i<\/jats:italic>) inoculation of human lung cancer LC\u20106 cells that secreted PTHrP, (<jats:italic>ii<\/jats:italic>) inoculation of human melanoma SEKI cells that secrete not PTHrP but LIF1, (<jats:italic>iii<\/jats:italic>) injection of heat\u2010killed <jats:italic>Mycobacterium<\/jats:italic> leading to arthritis (AA) and (<jats:italic>iv<\/jats:italic>) oral administration of a high dose of 1\u03b1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> that resulted in hypercalcemia. The LC\u20106\u2010bearing rats and AA rats were treated with or without anti\u2010PTHrP antibody and indomethacin, respectively, and the expression of the hypothalamic feeding\u2010regulating peptide mRNAs were examined by <jats:italic>in situ<\/jats:italic> hybridization histochemistry. The orexigenic peptide mRNAs, such as neuropeptide Y and agouti\u2010related protein, were significantly increased, and that of anorexigenic peptide mRNAs, such as proopiomelanocortin, cocaine\u2010 and amphetamine\u2010regulated transcript and corticotropin\u2010releasing hormone were significantly decreased when they developed cachectic syndromes and AA. A high dose of 1\u03b1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub> caused hypercalcemia and body weight loss but did not affect the expression of hypothalamic feeding\u2010regulating peptide mRNAs. The expressions of the hypothalamic feeding\u2010regulating peptides change commonly in different chronic cachectic models without relating to serum calcium levels.<\/jats:p>","DOI":"10.1002\/ijc.25535","type":"journal-article","created":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T21:41:00Z","timestamp":1278452460000},"page":"2215-2223","source":"Crossref","is-referenced-by-count":16,"title":["Similar changes of hypothalamic feeding\u2010regulating peptides mRNAs and plasma leptin levels in PTHrP\u2010, LIF\u2010secreting tumors\u2010induced cachectic rats and adjuvant arthritic 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